Evaluation of HIV-1 rapid tests and identification of alternative testing algorithms for use in Uganda

BMC Infectious Diseases

Table 5 Summary of possible algorithms with a performance as good as or better than the current algorithm ranked in order of cost^a

Rank	Screening	Confirmatory	Tie Breaker	Sensitivity	Specificity	PPV	NPV	FPR	FNR	Cost per test ($)
1^b	Determine	SD Bioline	StatPak	99.2	99.1	99	99.2	0.9	0.8	1.43
2	Determine	Medinostics	Statpak	99.1	99.2	99.2	99.1	0.8	0.9	1.43
3^b	Determine	Statpak	SD Bioline	99.2	99.1	99	99.2	0.9	0.8	1.43
4	Determine	StatPak	Medinostics	99.1	99.2	99.2	99.1	0.8	0.9	1.43
5^c	Determine	Statpak	Unigold	99.1	98.9	98.9	99.1	1.1	0.9	1.50
6	Determine	Unigold	Statpak	99.1	98.9	98.9	99.1	1.1	0.9	1.54
7	Determine	SD Bioline	Insti	99.1	99.0	99.0	99.1	1.0	0.9	1.78
8	Determine	Medinostics	Insti	99.1	99.1	99.1	99.1	0.9	0.9	1.78
9^b	Determine	Statpak	Insti	99.2	99.1	99.0	99.2	0.9	0.8	1.79
10	Determine	Unigold	Insti	99.1	98.9	98.9	99.1	1.1	0.9	1.89
11	Determine	Insti	Medinostics	99.1	99.1	99.1	99.1	0.9	0.9	2.05
12	Determine	Insti	SD Bioline	99.1	99.0	99.0	99.1	1.0	0.9	2.05
13	Determine	Insti	StatPak	99.2	99.1	99.0	99.2	0.9	0.8	2.05
14	Determine	Insti	Unigold	99.1	98.9	98.9	99.1	1.1	0.9	2.11
15	Insti	SD Bioline	Medinostics	99.1	99.4	99.4	99.1	0.6	0.9	4.61
16	Insti	Medinostics	SD Bioline	99.1	99.4	99.4	99.1	0.6	0.9	4.61
17	Insti	SD Bioline	StatPak	99.2	99.4	99.4	99.2	0.6	0.8	4.61
18	Insti	Medinostics	Statpak	99.1	99.4	99.4	99.1	0.6	0.9	4.61
19	Insti	Statpak	SD Bioline	99.2	99.4	99.4	99.2	0.6	0.8	4.61
20	Insti	StatPak	Medinostics	99.1	99.4	99.4	99.1	0.6	0.9	4.61
21	Insti	Statpak	Unigold	99.1	99.4	99.3	99.1	0.6	0.9	4.62
22	Insti	Unigold	Statpak	99.1	99.4	99.3	99.1	0.6	0.9	4.66

^aThe order of ranking followed the priority of: 1- Cost, 2-sensitivity, 3-specificity, 4-PPV, 5-NPV, 6-FPR, 7-FNR; ^b In bold are the proposed algorithms;
^cIn italics current algorithm

ISSN: 1471-2334