Fig. 8
From: IL-10+ NK and TGF-β+ NK cells play negative regulatory roles in HIV infection
Effects of rIL-10 and rTGF-β on perforin release by NK cells
PBMCs were co-cultured with rIL-10 and/or rTGF-β for 5 h, and then stimulated with PMA and ionomycin for 6 h. The inhibition of perforin release by NK cells by different concentrations of rIL-10 (a) or rTGF-β (b) was determined. The effects of treatment with both rIL-10 and rTGF-β on perforin release by NK cells were synergistic (c)