Table 2 Bivariate analysis of risk factors for mortality at 30Â days following the diagnosis on ICU
Factor | Survivors n = 29 | Non survivors n = 8 | p |
|---|---|---|---|
Gender, Male/Female | 17/12 | 3/5 | 0.28 |
Mean Age | 44.8 ± 16.5 | 67.2 ± 14.1 | <  0.004 |
Age > 45 years | 12 (41.3) | 8 (100) | <  0.004 |
Cause of ICU admission | |||
 Septic shock | 7 (24.1) | 2 (25) | = 0.9 |
 Cardiac failure | 9 (31) | 2 (25) | = 0.7 |
 Respiratory failure | 11 (37.9) | 1 (12.5) | = 0.18 |
 Renal failure | 2 (6.9) | 2 (25) | = 0.14 |
 Other causes | 0 (0) | 1 (12.5) |  |
Mean SAPS II | 29.6 ± 14.8 | 42.5 ± 22.9 | = 0.12 |
Mean SOFA | 5.9 ± 4.2 | 7.6 ± 5.0 | = 0.39 |
Charlson score | 2.5 ± 3.3 | 4.8 ± 3.3 | <  0.05 |
Charlson score > 3 | 10 (34.5) | 6 (75) | <  0.05 |
Diagnosis before ICU admission | 12 (41.3) | 0 (0) | <  0.03 |
RSIE acquired in ICU | 2 (6.9) | 1(12.5) | = 0.6 |
Community-acquired RSIE | 12 (41.4) | 6 (75) | = 0.09 |
Nosocomial endocarditis | 10 (34.5) | 4 (50) | = 0.42 |
ICED associated endocarditis | 2 (6.9) | 2 (25) | = 0.14 |
Source of infection | |||
 cutaneous | 4 (13.8) | 3 (37.5) | = 0.12 |
 IVDA | 8 (27.6) | 0 (0) | = 0.09 |
 Catheter related infection | 9 (31) | 1 (12.5) | = 0.28 |
 unknown | 6 (20.7) | 1 (12.5) | = 0.6 |
 other | 0 (0) | 1 (12.5) | = 0.05 |
Native tricuspid valve endocarditis | 28 (96.6) | 7 (87.5) | = 0.31 |
Severe tricuspid regurgitation | 9 (31) | 2 (25) | = 0.74 |
Vegetation size | 19.0 ± 9.7 | 23.0 ± 13.9 | = 0.59 |
LVEF < 50% | 6 (20.7) | 2 (25) | = 0.79 |
Neurological complications | 3 (10.3) | 2 (25) | <  0.02 |
Septic pulmonary embolism (n = 30)* | 23/26 (88.6) | 1/4 (25) | <  0.002 |
Pathogens | |||
 Methicillin-sensible S. aureus | 15 (51.7) | 2 (25) | = 0.2 |
 Methicillin-resistant S. Aureus | 6 (20.7) | 3 (37.5) | = 0.27 |
 Fungal | 2 (6.9) | 2 (25) | = 0.12 |
 Other pathogens | 8 (27.6) | 0 (0) | = 0.09 |
Aminoglycosides indication (n = 34)** | 27/28 | 5/6 | = 0.23 |
Aminoglycosides delivery (n = 34)** | 22/28 | 2/6 | <  0.05 |
Aminoglycosides conformity(n = 34)** | 21/28 | 1/6 | <  0.02 |
Surgical indication | 12 (41.4) | 2 (25) | = 0.39 |
 Indication: size of vegetation | 9 (31) | 2 (25) | = 0.42 |
 Indication: RHF | 6 (20.7) | 2 (25) | = 0.18 |
 Two indications | 3 (10.3) | 2 (25) | <  0.05 |
Surgical procedure performed | 13 (44.8) | 1 (12.5) | = 0.09 |