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SESOTHO trial (“Switch Either near Suppression Or THOusand”) – switch to second-line versus WHO-guided standard of care for unsuppressed patients on first-line ART with viremia below 1000 copies/mL: protocol of a multicenter, parallel-group, open-label, randomized clinical trial in Lesotho, Southern Africa

  • Alain Amstutz1, 2, 3Email authorView ORCID ID profile,
  • Bienvenu Lengo Nsakala4,
  • Fiona Vanobberghen1, 2,
  • Josephine Muhairwe4,
  • Tracy Renée Glass1, 2,
  • Beatrice Achieng4, 5,
  • Mamorena Sepeka5,
  • Katleho Tlali4, 5,
  • Lebohang Sao5, 6,
  • Kyaw Thin7,
  • Thomas Klimkait2, 8,
  • Manuel Battegay2, 3 and
  • Niklaus Daniel Labhardt1, 2, 3
BMC Infectious DiseasesBMC series – open, inclusive and trusted201818:76

https://doi.org/10.1186/s12879-018-2979-y

Received: 28 September 2017

Accepted: 29 January 2018

Published: 12 February 2018

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Open Peer Review reports

Pre-publication versions of this article are available by contacting info@biomedcentral.com.

Original Submission
28 Sep 2017 Submitted Original manuscript
4 Oct 2017 Author responded Author comments - Alain Amstutz
Resubmission - Version 2
4 Oct 2017 Submitted Manuscript version 2
9 Jan 2018 Author responded Author comments - Alain Amstutz
Resubmission - Version 3
9 Jan 2018 Submitted Manuscript version 3
17 Jan 2018 Author responded Author comments - Alain Amstutz
Resubmission - Version 4
17 Jan 2018 Submitted Manuscript version 4
Publishing
29 Jan 2018 Editorially accepted
12 Feb 2018 Article published 10.1186/s12879-018-2979-y

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article are available by contacting info@biomedcentral.com.

You can find further information about the peer review system here.

Authors’ Affiliations

(1)
Clinical Research Unit, Department of Medicine, Swiss Tropical and Public Health Institute, Basel, Switzerland
(2)
University of Basel, Basel, Switzerland
(3)
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
(4)
SolidarMed, Swiss Organization for Health in Africa, Maseru/Butha-Buthe, Lesotho
(5)
Butha-Buthe Government Hospital, Butha-Buthe, Lesotho
(6)
District Health Management Team Butha-Buthe, Butha-Buthe, Lesotho
(7)
Research Coordination Unit, Ministry of Health of Lesotho, Maseru, Lesotho
(8)
Molecular Virology, Department of Biomedicine, University of Basel, Basel, Switzerland

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