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Fig. 1 | BMC Infectious Diseases

Fig. 1

From: The impact of regular school closure on seasonal influenza epidemics: a data-driven spatial transmission model for Belgium

Fig. 1

Schematic illustration of the spatial age-structured metapopulation model. The metapopulation modeling scheme is composed of three layers. At the country scale, Belgium is modeled as a set of patches (here indicated with q and p) corresponding to municipalities coupled through mobility of individuals f pq (i) of age class i at time t. Within each municipality, population is divided into two age classes, children (c) and adults (a), whose mixing pattern is defined by the contact matrix C. Individuals resident of patch p and individuals commuting to that patch (e.g. resident of patch q) mix together following commuting. The figure reports as an example the contact matrix of a regular weekday (Eq. (3)). Mobility and mixing vary based on the calendar day (regular/holiday, weekday/weekend). Influenza disease progression at the individual level is modeled through a Susceptible-Exposed-Infectious-Recovered compartmental scheme, with β indicating the per-contact transmission rate, ε the rate from exposed to infectious state, μ the recovery rate

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