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Table 3 Factors associated with tuberculosis recurrence on conditional logistic regression

From: A nested case–control study of predictors for tuberculosis recurrence in a large UK Centre

  Unadjusted Odds ratio (95% CI) P value Adjusted odds ratio (95% CI) P value
Age 1.0 (1.0–1.0) 0.26 1.0(1.0–1.1) 0.09
Weight 1.0 (1.0–1.0) 0.29 1.0 (1.0–1.0) 0.46
Gender
 Male Reference   Reference  
 Female 1.0 (0.6–1.7) 1.00 1.1(0.5–2.7) 0.85
Ethnicity
 White Reference   Reference  
 Afro-Caribbean 0.8 (0.3–2.7) 0.75 5.4 (0.7–43.4) 0.13
 Indian subcontinent 1.0 (0.4–2.2) 0.96 8.5(1.8–39.3) <0.01
 Other 3.9 (0.6–24.8) 0.15 31.2(2.1–471.0) 0.01
UK Born 1.5 (0.8–2.8) 0.17 2.8(0.9–8.8) 0.07
Permanent residence 0.5 (0.3–8.0) 0.62 0.2(0.0–4.0) 0.26
Habitual alcohol consumption 2.2 (1.1–4.8) 0.03 1.8(0.6–5.7) 0.30
Habitual tobacco smoking 2.8 (1.4–5.6) <0.01 3.8(1.1–13.1) 0.04
Co-morbidities
 Diabetes mellitus 1.2 (0.5–2.7) 0.67 0.9 (0.2–2.8) 0.86
 HIV-1 seropositivity 1.7 (0.5–5.5) 0.40 4.1(0.7–23.1) 0.12
 Other comorbidities± 1.0 (0.3–3.5) 1.00 a  
Laboratory
 Haemoglobin (g/dl) 0.9 (0.8–1.0) 0.09 0.9 (0.7–1.2) 0.54
 White cell count (×109 cell/l) 1.0(1.0–1.1) 0.44 1.0 (0.8–1.1) 0.36
 Creatinine (μmol/l) 1.0 (1.0–1.0) 0.86 1.0(1.0–1.0) 0.41
Primary disease site
 PTB Reference   Reference  
 PTB + EPTB 0.5 (0.2–1.1) 0.09 0.7 (0.2–2.1) 0.49
 EPTB 0.6 (0.4–1.1) 0.12 1.4 (0.6–3.7) 0.49
Pulmonary cavitation 1.8 (0.9–3.6) 0.08 1.3 (0.5–3.9) 0.61
Microbiology
 AFB positive 2.3 (1.2–4.1) <0.01 1.7 (0.6–4.3) 0.30
 Culture positive 1.6 (0.8–2.9) 0.16 1.3 (0.5–3.2) 0.54
 Drug resistant 1.5 (0.5–4.1) 0.49 2.6 (0.5–13.8) 0.28
Treatment
 Standard regimen 0.7(0.3–1.4) 0.26 a  
ADR
 No ADR Reference   Reference  
 Grade 1/2 1.2 (0.4–4.1) 0.78 1.3 (0.3–6.1) 0.78
 Grade 3/4 2.3 (1.0–5.3) <0.05 5.6 (1.3–24.8) 0.02
 Treatment interruption 1.1 (0.4–2.6) 0.88 a  
 Immunosuppressing drugs 3.0 (1.2–7.1) 0.01 6.8 (1.9–24.4) <0.01
  1. ±Active cancer, end stage renal failure, solid organ transplant & rheumatology conditions
  2. HIV human immunodeficiency virus, PTB pulmonary tuberculosis, EPTB extrapulmonary tuberculosis, ADR adverse drug reaction, AFB acid fast bacillus
  3. a not included in the analysis due to multiple collinearity