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Table 3 Factors associated with tuberculosis recurrence on conditional logistic regression

From: A nested case–control study of predictors for tuberculosis recurrence in a large UK Centre

 

Unadjusted Odds ratio (95% CI)

P value

Adjusted odds ratio (95% CI)

P value

Age

1.0 (1.0–1.0)

0.26

1.0(1.0–1.1)

0.09

Weight

1.0 (1.0–1.0)

0.29

1.0 (1.0–1.0)

0.46

Gender

 Male

Reference

 

Reference

 

 Female

1.0 (0.6–1.7)

1.00

1.1(0.5–2.7)

0.85

Ethnicity

 White

Reference

 

Reference

 

 Afro-Caribbean

0.8 (0.3–2.7)

0.75

5.4 (0.7–43.4)

0.13

 Indian subcontinent

1.0 (0.4–2.2)

0.96

8.5(1.8–39.3)

<0.01

 Other

3.9 (0.6–24.8)

0.15

31.2(2.1–471.0)

0.01

UK Born

1.5 (0.8–2.8)

0.17

2.8(0.9–8.8)

0.07

Permanent residence

0.5 (0.3–8.0)

0.62

0.2(0.0–4.0)

0.26

Habitual alcohol consumption

2.2 (1.1–4.8)

0.03

1.8(0.6–5.7)

0.30

Habitual tobacco smoking

2.8 (1.4–5.6)

<0.01

3.8(1.1–13.1)

0.04

Co-morbidities

 Diabetes mellitus

1.2 (0.5–2.7)

0.67

0.9 (0.2–2.8)

0.86

 HIV-1 seropositivity

1.7 (0.5–5.5)

0.40

4.1(0.7–23.1)

0.12

 Other comorbidities±

1.0 (0.3–3.5)

1.00

a

 

Laboratory

 Haemoglobin (g/dl)

0.9 (0.8–1.0)

0.09

0.9 (0.7–1.2)

0.54

 White cell count (×109 cell/l)

1.0(1.0–1.1)

0.44

1.0 (0.8–1.1)

0.36

 Creatinine (μmol/l)

1.0 (1.0–1.0)

0.86

1.0(1.0–1.0)

0.41

Primary disease site

 PTB

Reference

 

Reference

 

 PTB + EPTB

0.5 (0.2–1.1)

0.09

0.7 (0.2–2.1)

0.49

 EPTB

0.6 (0.4–1.1)

0.12

1.4 (0.6–3.7)

0.49

Pulmonary cavitation

1.8 (0.9–3.6)

0.08

1.3 (0.5–3.9)

0.61

Microbiology

 AFB positive

2.3 (1.2–4.1)

<0.01

1.7 (0.6–4.3)

0.30

 Culture positive

1.6 (0.8–2.9)

0.16

1.3 (0.5–3.2)

0.54

 Drug resistant

1.5 (0.5–4.1)

0.49

2.6 (0.5–13.8)

0.28

Treatment

 Standard regimen

0.7(0.3–1.4)

0.26

a

 

ADR

 No ADR

Reference

 

Reference

 

 Grade 1/2

1.2 (0.4–4.1)

0.78

1.3 (0.3–6.1)

0.78

 Grade 3/4

2.3 (1.0–5.3)

<0.05

5.6 (1.3–24.8)

0.02

 Treatment interruption

1.1 (0.4–2.6)

0.88

a

 

 Immunosuppressing drugs

3.0 (1.2–7.1)

0.01

6.8 (1.9–24.4)

<0.01

  1. ±Active cancer, end stage renal failure, solid organ transplant & rheumatology conditions
  2. HIV human immunodeficiency virus, PTB pulmonary tuberculosis, EPTB extrapulmonary tuberculosis, ADR adverse drug reaction, AFB acid fast bacillus
  3. a not included in the analysis due to multiple collinearity