From: A nested case–control study of predictors for tuberculosis recurrence in a large UK Centre
Unadjusted Odds ratio (95% CI) | P value | Adjusted odds ratio (95% CI) | P value | |
---|---|---|---|---|
Age | 1.0 (1.0–1.0) | 0.26 | 1.0(1.0–1.1) | 0.09 |
Weight | 1.0 (1.0–1.0) | 0.29 | 1.0 (1.0–1.0) | 0.46 |
Gender | ||||
Male | Reference | Reference | ||
Female | 1.0 (0.6–1.7) | 1.00 | 1.1(0.5–2.7) | 0.85 |
Ethnicity | ||||
White | Reference | Reference | ||
Afro-Caribbean | 0.8 (0.3–2.7) | 0.75 | 5.4 (0.7–43.4) | 0.13 |
Indian subcontinent | 1.0 (0.4–2.2) | 0.96 | 8.5(1.8–39.3) | <0.01 |
Other | 3.9 (0.6–24.8) | 0.15 | 31.2(2.1–471.0) | 0.01 |
UK Born | 1.5 (0.8–2.8) | 0.17 | 2.8(0.9–8.8) | 0.07 |
Permanent residence | 0.5 (0.3–8.0) | 0.62 | 0.2(0.0–4.0) | 0.26 |
Habitual alcohol consumption | 2.2 (1.1–4.8) | 0.03 | 1.8(0.6–5.7) | 0.30 |
Habitual tobacco smoking | 2.8 (1.4–5.6) | <0.01 | 3.8(1.1–13.1) | 0.04 |
Co-morbidities | ||||
Diabetes mellitus | 1.2 (0.5–2.7) | 0.67 | 0.9 (0.2–2.8) | 0.86 |
HIV-1 seropositivity | 1.7 (0.5–5.5) | 0.40 | 4.1(0.7–23.1) | 0.12 |
Other comorbidities± | 1.0 (0.3–3.5) | 1.00 | a | |
Laboratory | ||||
Haemoglobin (g/dl) | 0.9 (0.8–1.0) | 0.09 | 0.9 (0.7–1.2) | 0.54 |
White cell count (×109 cell/l) | 1.0(1.0–1.1) | 0.44 | 1.0 (0.8–1.1) | 0.36 |
Creatinine (μmol/l) | 1.0 (1.0–1.0) | 0.86 | 1.0(1.0–1.0) | 0.41 |
Primary disease site | ||||
PTB | Reference | Reference | ||
PTB + EPTB | 0.5 (0.2–1.1) | 0.09 | 0.7 (0.2–2.1) | 0.49 |
EPTB | 0.6 (0.4–1.1) | 0.12 | 1.4 (0.6–3.7) | 0.49 |
Pulmonary cavitation | 1.8 (0.9–3.6) | 0.08 | 1.3 (0.5–3.9) | 0.61 |
Microbiology | ||||
AFB positive | 2.3 (1.2–4.1) | <0.01 | 1.7 (0.6–4.3) | 0.30 |
Culture positive | 1.6 (0.8–2.9) | 0.16 | 1.3 (0.5–3.2) | 0.54 |
Drug resistant | 1.5 (0.5–4.1) | 0.49 | 2.6 (0.5–13.8) | 0.28 |
Treatment | ||||
Standard regimen | 0.7(0.3–1.4) | 0.26 | a | |
ADR | ||||
No ADR | Reference | Reference | ||
Grade 1/2 | 1.2 (0.4–4.1) | 0.78 | 1.3 (0.3–6.1) | 0.78 |
Grade 3/4 | 2.3 (1.0–5.3) | <0.05 | 5.6 (1.3–24.8) | 0.02 |
Treatment interruption | 1.1 (0.4–2.6) | 0.88 | a | |
Immunosuppressing drugs | 3.0 (1.2–7.1) | 0.01 | 6.8 (1.9–24.4) | <0.01 |