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Table 3 Crude and adjusted hazard ratios for the association between variable and the risk of NTM infection during all follow-up period

From: The risk of nontuberculous mycobacterial infection in patients with Sjögren’s syndrome: a nationwide, population-based cohort study

 

Univariate analysis

Model A

Model B

 

HR

(95%CI)

HR

(95%CI)

HR

(95%CI)

Group

 Non- SS

Reference

Reference

Reference

Reference

Reference

Reference

 SS

7.66

(2.36–24.94)

3.17

(0.70–14.24)

  

 SS treated without immunosuppressants

2.47

(0.31–19.53)

  

1.95

(0.24–15.68)

 SS treated with immunosuppressants

25.45

(6.88–94.05)

  

17.77

(4.53–69.61)

Age

  < 50 years

Reference

Reference

Reference

Reference

Reference

Reference

  ≥ 50 years

1.82

(0.50–6.60)

1.63

(0.43–6.19)

1.64

(0.43–6.24)

Gender

 Female

Reference

Reference

Reference

Reference

Reference

Reference

 Male

3.50

(1.08–11.36)

3.34

(1.02–10.96)

3.27

(0.99–10.74)

CCI group

 0

Reference

Reference

Reference

Reference

Reference

Reference

  ≥ 1

1.55

(0.48–5.04)

0.97

(0.29–3.30)

1.00

(0.30–3.41)

Medications

 Immunosuppressants

13.74

(3.78–49.94)

4.89

(0.94–25.33)

  

 Methotrexate

18.74

(4.15–84.56)

    

 Azathioprin

21.26

(4.71–95.91)

    

 Cyclophosphamide

27.86

(6.18–125.70)

    

 Steroid

3.94

(1.08–14.37)

2.65

(0.68–10.26)

2.72

(0.70–10.55)

  1. Abbreviations: SS Sjögren’s Syndrome, CCI Charlson cormorbidity