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Table 1 Abilities of the IFNγ in response to PPD, E6-C10, DosR and Rpf antigens to discriminate between LTBI and PTB

From: Potential of DosR and Rpf antigens from Mycobacterium tuberculosis to discriminate between latent and active tuberculosis in a tuberculosis endemic population of Medellin Colombia

Antigens PTB Median (IQR) HHC-LTBI Median (IQR) p-value* AUC (95% CI) Cut-off (pg/ml) Sensitivity (%) Specificity (%)
DosR
 Rv1737c 70.7 (18.8–664.2) 1742.0 (209.2–2528.0) 0.0041 0.76 (0.60–0.92) 1014.96 65.0 90.5
 Rv2029c 233.4 (38.9–961.3) 2421.0 (1182.0–4426.0) 0.0003 0.82 (0.69–0.96) 763.15 90.0 76.2
 Rv2628 452.3 (29.1–1363.0) 2489.0 (281.0–7006.0) 0.0173 0.72 (0.55–0.88) 1569.41 65.0 81.0
Rpf
 Rv0867c 121.8 (19.3–437.2) 576.8 (181.0–1224.0) 0.0091 0.74 (0.58–0.89) 454.89 65.0 81.0
 Rv2389c 15.5 (6.3–200.3) 349.5 (74.72–932.6) 0.0126 0.73 (0.57–0.89) 28.36 85.0 61.9
 Control
 E6-C10 56.5 (2.4–1027.0) 2623.0 (461.0–6761.0) 0.0006 0.80 (0.66–0.94) 1070.36 75.0 81.0
 PPD 2355.0 (401.3–3949.0) 5453.0 (2137.0–18,874.0) 0.0042 0.76 (0.60–0.91) 4464.11 65.0 86.0
  1. IQR Interquartile Range. AUC Area Under the ROC Curve. CI Confidence Interval
  2. *p-value for the Mann-Whitney test