Table 1 Abilities of the IFNγ in response to PPD, E6-C10, DosR and Rpf antigens to discriminate between LTBI and PTB
Antigens | PTB Median (IQR) | HHC-LTBI Median (IQR) | p-value* | AUC (95% CI) | Cut-off (pg/ml) | Sensitivity (%) | Specificity (%) |
|---|---|---|---|---|---|---|---|
DosR | |||||||
 Rv1737c | 70.7 (18.8–664.2) | 1742.0 (209.2–2528.0) | 0.0041 | 0.76 (0.60–0.92) | 1014.96 | 65.0 | 90.5 |
 Rv2029c | 233.4 (38.9–961.3) | 2421.0 (1182.0–4426.0) | 0.0003 | 0.82 (0.69–0.96) | 763.15 | 90.0 | 76.2 |
 Rv2628 | 452.3 (29.1–1363.0) | 2489.0 (281.0–7006.0) | 0.0173 | 0.72 (0.55–0.88) | 1569.41 | 65.0 | 81.0 |
Rpf | |||||||
 Rv0867c | 121.8 (19.3–437.2) | 576.8 (181.0–1224.0) | 0.0091 | 0.74 (0.58–0.89) | 454.89 | 65.0 | 81.0 |
 Rv2389c | 15.5 (6.3–200.3) | 349.5 (74.72–932.6) | 0.0126 | 0.73 (0.57–0.89) | 28.36 | 85.0 | 61.9 |
 Control | |||||||
 E6-C10 | 56.5 (2.4–1027.0) | 2623.0 (461.0–6761.0) | 0.0006 | 0.80 (0.66–0.94) | 1070.36 | 75.0 | 81.0 |
 PPD | 2355.0 (401.3–3949.0) | 5453.0 (2137.0–18,874.0) | 0.0042 | 0.76 (0.60–0.91) | 4464.11 | 65.0 | 86.0 |