Identification of uncommon oral yeasts from cancer patients by MALDI-TOF mass spectrometry

BMC Infectious Diseases

Table 3 In vitro susceptibilities of 157 clinical isolates to four antifungal agents. MIC range, geometric mean, MIC₅₀, and MIC₉₀ values are expressed in μg/ml

(No. of strains)	Antifungal agent	MIC μg/ml
(No. of strains)	Antifungal agent	MIC range	MIC₅₀	MIC₉₀	GM	MODE
All clinical strains (n = 157)	Fluconazole	0.063–64	2	8	1.65	4
	Amphotericin B	0.016–16	1	4	0.50	1
	Caspofungin	0.008–8	0.5 mg/ml	2 μg/ml	0.34	0.5
	Anidulafungin	0.008–1	0.063	0.5	0.06	0.063
C. albicans (n = 82)	Fluconazole	0.063–64	0.5	8	0.80	0.5
	Amphotericin B	0.016–16	1	4	0.62	1
	Caspofungin	0.008–8	0.25	1	0.22	0.5
	Anidulafungin	0.008–0.25	0.031	0.125	0.03	0.016
C. dubliniensis (n = 6)	Fluconazole	0.063–0.125	0.125	0.125	0.11	0.125
	Amphotericin B	0.016–2	0.031	2	0.09	0.031
	Caspofungin	0.25–2	0.5	2	0.5	0.5
	Anidulafungin	0.008–0.125	0.125	0.25	0.07	0.016
C. glabrata (n = 40)	Fluconazole	0.25–64	8	64	7.08	4
	Amphotericin B	0.016–4	1	2	0.62	1
	Caspofungin	0.008–2	0.5	2	0.40	1
	Anidulafungin	0.016–1	0.063	1	0.12	1
C. krusei (= Pichia kudriavzevii) (n = 16)	Fluconazole	0.25–64	8	64	7.33	4
	Amphotericin B	0.063–2	0.5	1	0.59	1
	Caspofungin	0.063–4	2	4	1.13	1
	Anidulafungin	0.016–0.25	0.125	0.25	0.07	0.25
C. tropicalis (n = 7)	Fluconazole	0.063–8	4	8	0.63	0.063
	Amphotericin B	0.031–2	1	2	0.39	2
	Caspofungin	0.031–8	0.5	8	0.39	0.25
	Anidulafungin	0.008–0.063	0.063	0.063	0.063	0.063
C. kefyr = (Kluyveromyces marxianus) (n = 6)	Fluconazole	0.25–32	4	32	2.82	4
	Amphotericin B	0.016–1	0.5	1	0.15	0.5
	Caspofungin	0.125–0.05	0.25	0.5	0.25	0.125
	Anidulafungin	0.031–0.063	0.063	0.5	0.04	0.063

ISSN: 1471-2334