Application of extracorporeal membrane oxygenation in patients with severe acute respiratory distress syndrome induced by avian influenza A (H7N9) viral pneumonia: national data from the Chinese multicentre collaboration

Table 1 General conditions and outcomes of patients with ECMO therapy

Variable	Total (n = 35)	Successfully weaned group (n = 14)	Unsuccessfully weaned group (n = 21)	P value
Gender, number (%)
Male	23(65.7)	9(64.3)	14(66.7)	1.00
Age, years, mean ± SD	57 ± 1	51 ± 10	60 ± 12	0.02*
Underlying Diseases, number (%)
Hypertension	19(54.3)	7(50)	12(57.1)	0.74
Diabetes	13(37.1)	1(7.1)	12(57.1)	< 0.01*
Cerebrovascular disease	5(14.3)	3(21.4)	2(9.5)	0.37
History of steroid and immunosuppressant within 1 month	8(22.9)	4(28.6)	4(19.0)	0.69
Pregnancy, number (%)	1(2.9)	0(0.0)	1(47.6)	1.00
Onset to NAI	9 ± 5	7 ± 3	11 ± 6	0.04*
Onset to ECMO	10 ± 3	10 ± 3	10 ± 3	0.97
Organ support pre-ECMO
High-dose vasoactive drugs^a, number (%)	20(57.1)	6(42.9)	14(63.6)	0.31
Rescue ventilation strategies^b, number (%)	23(65.7)	6(43.9)	17(81.0)	0.03*
Duration of IPPV, days, mean ± SD	5 ± 1	2 ± 1	6 ± 4	< 0.01*
SOFA Score	9 ± 3	7 ± 2	10 ± 4	0.02*
Murray Score	3.6 ± 0.4	3.6 ± 0.5	3.6 ± 0.4	0.95
PaO₂/FiO₂ pre-ECMO, mmHg, mean ± SD	78 ± 23	89 ± 24	71 ± 20	0.04*
Duration of ECMO, days, median (IQR)	8(5–13)	10(7–13)	7(3–16)	0.48
Total Duration of IPPV, days, mean ± SD	20 ± 8	23 ± 13	18 ± 15	0.36
Clinical outcomes
Mortality, number (%)	22 (63)	1 (7.1)	21 (100)	< 0.01*
Length of stay in ICU, days, mean ± SD	27 ± 14	33 ± 12	24 ± 14	0.081
Length of hospitalization, days, mean ± SD	31 ± 14	39 ± 10	27 ± 14	0.010*

Note: ^ahigh-dose vasoactive drugs [17] infer to: noradrenaline > 0.5 μg/kg/min or dopamine > 20 μg/kg/min; ^brescue ventilation strategies includes recruitment maneuver (RM), prone position ventilation (PP) and high frequency oscillatory ventilation (HFOV)
NAI neuraminidase inhibitors, IPPV invasive positive pressure ventilation, ECMO extracorporeal membrane oxygenation, SOFA score sequential organ failure score, ICU intensive care unit
We made comparison between successfully weaned and unsuccessfully weaned group using t-test, x² test or Wilcoxon rank-sum test, and P values <0.05 were considered significant, marked as *

ISSN: 1471-2334