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Table 1 Performance characteristics of LPA for the detection RIF, INH, OFX, KAN and EMB

From: Comparison of line probe assay to BACTEC MGIT 960 system for susceptibility testing of first and second-line anti-tuberculosis drugs in a referral laboratory in South Africa

Drug

No of isolates

LPA + MGIT R

LPA + MGIT S

LPA R MGIT S

LPA S MGIT R

Sensitivity (%)

Specificity (%)

PPV (%)

NPV (%)

Agreement (%)

K-Value

aRIF

97

14

73

10

0

100 (76.8–100)

87.9(78.9–94.1)

58.3 (43.9–71.5)

100

89.7

0.68

aINH

97

43

51

3

0

100 (91.8–100)

94.4 (84.6–98.8)

93.5 (82.7–97.7)

100

96.9

0.93

aOFL

90

9

74

7

0

100 (66.3–100)

91.4 (83.0–96.4)

56.2(38.8–72.3)

100

92.2

0.68

aKAN

90

3

85

2

0

100 (29.2–100)

97.7(91.9–99.7)

60.0(27.60–85.5)

100

97.8

0.74

aEMB

90

15

58

7

10

60 (38.7–78.9)

89.2(79.06–95.56)

68.2(49.8–82.2)

85.3(78.1–90.4)

81.1

0.54

  1. a RIF Rifampicin, INH Isoniazid, OFX Ofloxacin, KAN Kanamycin, EMB Ethambutol, S susceptible, R resistant, LPA Line Probe Assay, PPV positive predictive value, NPV negative predictive value