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Table 2 Comparison of clinical characteristics between sporadic and familial cases of isolated congenital asplenia

From: Sporadic isolated congenital asplenia with fulminant pneumococcal meningitis: a case report and updated literature review

  Sporadic n = 32 Familial n = 41 P value
Age at diagnosis, years 2.1 (0.8–34.2) 1.0 (0.6–3.0) 0.04
Male sex 11a (44) 25(61) 0.18
Clinical events
 Sepsis and/ or meningitis 25(78) 24 (58) 0.08
 Others 6 (19) 2 (5) 0.06
 Asymptomatic 1 (3) 15 (37) 0.001
Pathogens
 S. pneumoniae 16b (62) 14c (56) 0.69
 H. influenzae 5b (19) 3c (12) 0.48
 Others 3b (12) 0c (0) 0.08
Howell- Jolly bodies 18 (56) 17 (41) 0.21
Outcome
 Death 12 (38) 16 (39) 0.68
  1. Values are presented as median (interquartile range) or number (percentage). P < 0.05 is considered to be significant. adata from 25 patients were available. bdata from 26 patients were available. cdata from 25 patients were available