Total Population | With Lipodystrophy | Without Lipodystrophy | |||||||
---|---|---|---|---|---|---|---|---|---|
Baseline | 1 year after | p | Baseline | 1 year after | P | Baseline | 1 year after | p | |
Weight [Kg, mean (sd)] | 68.7 (11.9) | 67.8 (11.8) | 0.474 | 67.8 (9.6) | 65.7 (12.0) | 0.360 | 69.5 (13.5) | 69.5 (13.5) | 0.977 |
Height [m, mean (sd)] | 1.65 (0.1) | 1.65 (0.1) | – | 1.64 (0.08) | 1.64 (0.08) | – | 1.66 (0.09) | 1.66 (0.09) | – |
BMI [(Kg/m2), mean (sd)] | 25.2 (4.3) | 25.0 (4.9) | 0.547 | 25.2 (3.8) | 24.5 (4.7) | 0.359 | 25.2 (4.7) | 25.4 (5.1) | 0.849 |
Waist circumference [cm, mean (sd)] | 91.4 (11.5) | 90.9 (10.8) | 0.654 | 91.6 (9.9) | 89.7 (11.2) | 0.402 | 91.4 (12.8) | 92.0 (10.4) | 0.804 |
Hip circumference [cm, mean (sd)] | 94.0 (7.8) | 93.2 (6.8) | 0.496 | 91.9(6.4) | 92.6 (7.0) | 0.561 | 95.7(8.6) | 93.6 (6.7) | 0.120 |
Thigh circumference [cm, mean (sd)] | 48.0 (5.2) | 45.3 (4.2) | <0.001 | 47.2 (5.2) | 45.0 (4.14) | 0.023 | 48,7 (5.1) | 45.5 (4.4) | <0.001 |
Arm circumference [cm, mean (sd)] | 27.0 (2.9) | 26.1 (2.8) | 0.049 | 27.0 (2.7) | 25.9 (2.9) | 0.082 | 27.0 (3.1) | 26.5 (2.8) | 0.353 |
Neck circumference [cm, mean (sd)] | 37.7 (3.5) | 36.9 (3.5) | 0.143 | 37.6 (3.3) | 36.8 (3.9) | 0.327 | 37.8 (3.6) | 37.1 (3.2) | 0.322 |
Waist/ hip circumference ratio [mean (sd)] | 0.97 (0.08) | 0.97 (0.08) | 0.786 | 1.00 (0.07) | 0.97 (0.09) | 0.086 | 0.95 (0.09) | 0.98 (0.08) | 0.066 |
Fat mass [%, mean (sd)] DXA | |||||||||
Total | 20.5 (11.4) | 21.6 (10.4) | 0.554 | 17.8 (8.0) | 19.9 (10.5) | 0.264 | 22.6 (13.1) | 22.9 (10.1) | 0.941 0.418 |
Trunk | 23.5 (11.6) | 24.8 (10.8) | 0.561 | 22.7 (8.6) | 22.7 (11.2) | 0.980 | 24.1 (13.5) | 26.5 (10.2) | |
Leg | 16.7 (13.8) | 16.2 (11.0) | 0.898 | 9.7 (6.7) | 15.0 (10.4) | 0.007 | 22.3 (15.4) | 17.2 (11.5) | 0.088 |
Arm | 21.3 (15.2) | 23.8 (15.0) | 0.267 | 18.7(13.3) | 22.4 (15.8) | 0.232 | 23.4 (16.3) | 24.9 (14.4) | 0.631 |
Fat mass [Kg, mean (sd)] DXA | |||||||||
Total | 14.5 (9.5) | 14.7 (8.3) | 0.867 | 12.1 (6.7) | 13.1 (7.7) | 0.406 | 16.4 (11.0) | 16.0 (8.6) | 0.736 |
Trunk | 8.7 (5.4) | 9.0 (5.0) | 0.897 | 8.4 (4.3) | 8.0 (4.9) | 0.766 | 9.1 (6.2) | 9.8 (5.1) | 0.641 |
Leg | 3.5 (3.0) | 3.3 (2.5) | 0.810 | 1.8 (1.3) | 2.8 (2.0) | 0.008 | 4.7 (3.4) | 3.6 (2.8) | 0.047 |
Arm | 1.7 (1.5) | 1.8 (1.3) | 0.293 | 1.4 (1.2) | 1.7 (1.3) | 0.238 | 1.9 (1.7) | 1.9 (1.3) | 0.744 |
Body Fat Mass by Quantitative CT | |||||||||
Total fat [cm2, mean (sd)] | 266.8 (158.4) | 274.5 (146.0) | 0.625 | 259.6 (112.9) | 249.6 (160.5) | 0.708 | 272.6 (188.1) | 295.3 (130.4) | 0.361 |
VAT [cm2, mean (sd)] | 133.8 (83.2) | 136.0 (85.1) | 0.670 | 154.8 (59.7) | 126.2 (97.2) | 0.049 | 116.8 (95.4) | 144.2 (73.3) | 0.024 |
SAT [cm2, mean (sd)] | 133.0 (110.4) | 139.3 (95.7) | 0.314 | 104.9 (85.2) | 125.2 (95.8) | 0.180 | 155.8 (123.2) | 151.1 (94.8) | 0.848 |
VAT/SAT ratio [cm2, mean (sd)] | 1.8 (1.8) | 1.6 (1.8) | 0.298 | 2.4 (1.7) | 1.6 (1.6) | 0.019 | 1.3 (1.8) | 1.6 (1.9) | 0.185 |
Systolic blood pressure [mmHg, mean (sd)] | 122.9 (18.0) | 117.2 (18.1) | 0.005 | 124.0 (16.1) | 119.3 (20.9) | 0.072 | 122.0 (19.4) | 115.6 (15.5) | 0.027 |
Diastolic blood pressure [mmHg, mean (sd)] | 78.8 (11.6) | 71.8 (8.9) | <0.001 | 79.2 (11.1) | 72.2 (8.6) | 0.001 | 78.5 (12.1) | 71.6 (9.2) | <0.001 |
Glucose 0 min [mg/dL, mean (sd)] | 112.0 (49.6) | 101.2 (25.6) | 0.481 | 119.1 (52.1) | 104.6 (28.7) | 0.307 | 106.4 (47.1) | 99.4 (22.8) | 0.992 |
Glucose 2 h [mg/dL, mean (sd)] | 129.5 (47.4) | 137.3 (47.6) | 0.445 | 138.5 (47.7) | 137.7 (47.5) | 0.819 | 122.3 (46.3) | 136.9 (48.2) | 0.451 |
Insulin 0 min [μU/mL, mean (sd)] | 10.7 (10.4) | 13.3 (14.8) | 0.166 | 10.9 (6.5) | 12.1 (9.9) | 0.419 | 10.5 (12.8) | 14.1 (17.7) | 0.227 |
Insulin 2 h [μU/mL, mean (sd)] | 76.5 (131.5) | 71.8 (60) | 0.886 | 105.9 (186.8) | 69.9 (60.4) | 0.220 | 53.1 (49.2) | 73.3 (59.9) | 0.307 |
HOMA [mean (sd)] | 3.1 (3.2) | 3.5 (4.8) | 0.552 | 3.2 (2.5) | 3.2 (2.9) | 0.857 | 2.9 (3.6) | 3.8 (5.8) | 0.369 |
A1c [% mean (sd)] | 5.8 (1.2) | 5.5 (0.8) | 0.095 | 5.9 (1.1) | 5.5 (0.9) | 0.096 | 5.6 (1.2) | 5.4 (0.7) | 0.556 |
Total cholesterol [mg/dL, mean (sd)] | 219.5 (56.8) | 204.7 (41.4) | 0.012 | 226 (57.6) | 203.8 (41.9) | 0.007 | 213.6 (56.0) | 205.4 (41.2) | 0.396 |
LDL-cholesterol [mg/dL, mean (sd)] | 118.0 (49.2) | 135.7 (31.3) | 0.001 | 123.7 (49.2) | 133.9 (28.4) | 0.153 | 113.5 (49.2) | 137.2 (33.6) | 0.001 |
HDL-cholesterol [mg/dL, mean (sd)] | 43.8 (11.7) | 48.6 (13.3) | 0.012 | 43.6 (11.3) | 50.6 (14.6) | 0.018 | 43.9 (12.1) | 46.9 (12.0) | 0.280 |
Non-HDL cholesterol [mg/dL, mean (sd)] | 175.7 (52.3) | 156.2 (37.6) | <0.001 | 183.2 (52.2) | 153.2 (37.6) | <0.001 | 169.8 (52.0) | 158.5 (37.6) | 0.192 |
Triglycerides [mg/dL, mean (sd)] | 290.8 (189.0) | 180.5 (110.5) | <0.001 | 298.9 (186.9) | 165.6 (107.2) | <0.001 | 284.4 (191.7) | 192.3 (112.5) | 0.001 |
Apo A1 [mg/dL, mean (sd)] | 111 (21) | 126.4 (24.0) | <0.001 | 111.6 (16.6) | 130.0 (25.2) | 0.001 | 110.4 (23.9 | 123.7 (22.8) | 0.002 |
Apo B [mg/dL, mean (sd)] | 104.7 (25.3) | 101.4 (21.7) | <0.001 | 104.8 (26.7) | 100.0 (21.6) | 0.126 | 104.7 (24.4) | 102.4 (22.0) | 0.706 |
Ratio apo B/apo A1 [mean (sd)] | 0.97 (0.3) | 0.83 (0.3) | <0.001 | 0.95 (0.3) | 0.79 (0.2) | 0.001 | 0.98 (0.3) | 0.87 (0.3) | 0.02 |
Lp (a) [mg/dL, mean (sd)] | 28.3 (32.0) | 36.3 (43.3) | 0.289 | 27.5 (33.5 | 44.4 (47.8) | 0.102 | 28.9 (30.9) | 30.1 (38.7) | 0.906 |
Homocysteine [μmol/L, mean (sd)] | 9.5 (3.8) | 11.1 (4.8) | 0.005 | 9.7 (3.5) | 12.1 (5.2) | 0.008 | 9.4 (4.1) | 10.3 (4.3) | 0.179 |
CRP [mg/L, mean (sd)] | 5.6 (12.8) | 5.1 (11.3) | 0.147 | 4.3 (4.7) | 6.1 (14.4) | 0.857 | 6.6 (16.6) | 4.3 (8.0) | 0.038 |
hsCRP [mg/dL, mean (sd)] | 0.6 (1.2) | 0.5 (1.2) | 0.030 | 0.34 (0.31) | 0.65 (1.6) | 0.225 | 0.83 (1.5) | 0.43 (0.8) | 0.066 |
Lactates [mmol/L, mean (sd)] | 1.2 (0.5) | 1.4 (0.6) | 0.002 | 1.3 (0.6) | 1.4 (0.6) | 0.307 | 1.1 (0.48) | 1.4 (0.5) | 0.001 |
NT-ProBNP [pg/mL, mean (sd)] | 36.8 (59.0) | 39.0 (63.0) | 0.241 | 31.6 (31.9) | 35.9 (33.2) | 0.177 | 41.2 (74.8) | 41.3 (79.0) | 0.769 |
Fibrinogen [mg/dL, mean (sd)] | 347.3 (104.4) | 332.6 (79,0) | 0.611 | 342.9 (105.9) | 333.8 (80.1) | 0.841 | 350.8 (103.8) | 331.6 (78.8) | 0.370 |
Microalbumin [mg/L, mean (sd)] | 58.2 (151.4) | 36.0 (159.8) | 0.527 | 40.6 (91.3) | 20.5 (35.6) | 0.551 | 76.7 (196.6) | 47.7 (209.3) | 0.852 |
Uric acid [mg/L, mean (sd)] | 47.7 (14.0) | 44.1 (14.6) | 0.022 | 49.8 (12.8) | 43.7 (13.0) | 0.005 | 45.9 (14.6) | 474.3 (15.8) | 0.470 |
Carotid IMT [mm, mean (sd)] | 0.77 (0.23) | 0.87 (0.32) | 0.001 | 0.82 (0.26) | 0.92 (0.33) | 0.037 | 0.73 (0.20) | 0.84 (0.30) | 0.012 |
Metabolic Syndrome (%) | 58 (51.3) | 48 (43.2) | 0.203 | 27 (54.0) | 19 (38.8) | 0.134 | 31 (49.2) | 29 (46.8) | 0.851 |