Table 1 Basal sample characteristics according to the presence of lipodystrophy defined by FMR
Without Lipodystrophy defined by FMR | With Lipodystrophy defined by FMR | P | |
|---|---|---|---|
n (%) | 64 | 51 | – |
Gender [n(%)] | |||
Male | 49 (76.6%) | 42(82.4%) | 0.448 |
Female | 15(23.4%) | 9(17.6%) | |
Age [years, mean (sd)] | 45 (12.2) | 49(9.9) | 0.052 |
Duration of HIV infection [years, mean (sd)] | 7.2 (3.8) | 8.5(3.7) | 0.036 |
cART [years, mean (sd)] | 5.9 (3.6) | 7.9 (3.5) | 0.001 |
Weight [Kg, mean (sd)] | 69.5 (13.5) | 67.8 (9.6) | 0.410 |
Height [m, mean (sd)] | 1.66 (0.09) | 1.64 (0.08) | 0.188 |
BMI [(Kg/m2), mean (sd)] | 25.2 (4.7) | 25.2 (3.8) | 0.976 |
Waist circumference [cm, mean (sd)] | 91.3 (12.7) | 91.6 (9.9) | 0.877 |
Hip circumference [cm, mean (sd)] | 95.7(8.5) | 91.9(6.4) | 0.006 |
Thigh circumference [cm, mean (sd)] | 48,7 (5.1) | 47.1(5.2) | 0.113 |
Arm circumference [cm, mean (sd)] | 26.9 (3.0) | 27.0 (2.7) | 0.939 |
Neck circumference [cm, mean (sd)] | 37.8 (3.6) | 37.6 (3.3) | 0.829 |
Waist/ hip circumference ratio [mean (sd)] | 0.95 (0.09) | 0.99 (0.07) | 0.003 |
CD4 cell count [cells/mm3, mean (sd)] | 522.9 (288.7) | 584.6 (331.9) | 0.289 |
HIV RNA (<50) [n (%)] | 52 (81.3%) | 47 (92.92%) | 0.093 |
HIV risk factor [n (%)] | |||
Injecting drug user | 19 (29.7%) | 11 (21.6%) | 0.073 |
Homosexual contact | 39 (60.9%) | 27 (52.9%) | |
Heterosexual contact | 4 (6.3%) | 11 (21.6%) | |
Others | 1(1.6%) | 2 (3.9%) | |
CDC [n (%)] | |||
A | 32 (50.0%) | 31(60.8%) | 0.248 |
B | – | – | |
C | 32 (50.0) | 20 (39.2) | |
ART [n (%)] | |||
PI | 32 (50.0%) | 30 (58.8%) | 0.346 |
NNRTI | 31 (48.4%) | 23 (45.1%) | 0.721 |
NRTI | 60 (93.8%) | 50 (98.0%) | 0.380 |
Smoking history [n (%)] | |||
Never | 19 (30.2%) | 20 (39.2) | 0.556 |
Current | 33 (52.4%) | 22 (43.1%) | |
Former | 11 (17.5%) | 9 (17.6%) | |
Familial history of CVD [n (%)] | 23 (35.9%) | 21 (41.2%) | 0.566 |
Taking medications [n (%)] | |||
Statins | 14 (22.2%) | 15 (29.4%) | 0.381 |
Fibrates | 29 (46.0%) | 27 (52.9%) | 0.463 |
Oral anti-diabetics | 9 (14.3%) | 12 (23.5%) | 0.306 |
Insulin | 4 (6.3%) | 4 (7.8%) | 0.999 |
Anti-hypertensive drugs | 13 (20.3%) | 12 (24.0%) | 0.637 |
Fat mass [%, mean (sd)] DXA | |||
Total | 22.6 (13.1) | 17.8 (8.0) | 0.017 |
Trunk | 24.1 (13.5) | 22.7 (8.6) | 0.508 |
Leg | 22.3 (15.4) | 9.7 (6.7) | <0.001 |
Arm | 23.4 (16.3) | 18.7 (13.3) | 0.095 |
Fat mass [Kg, mean (sd)] DXA | |||
Total | 16.4 (11.0) | 12.1 (6.6) | 0.012 |
Trunk | 9.1 (6.2) | 8.4 (4.3) | 0.470 |
Leg | 4.7 (3.4) | 1.8 (1.3) | <0.001 |
Arm | 1.9 (1.7) | 13.8 (1.2) | 0.063 |
Body Fat Mass by Quantitative CT | |||
Total fat [cm2, mean (sd)] | 272.6 (188.1) | 259.6 (112.9) | 0.651 |
VAT [cm2, mean (sd)] | 116.8 (95.4) | 154.8 (59.7) | 0.011 |
SAT [cm2, mean (sd)] | 155.8 (123.2) | 104.8 (85.2) | 0.011 |
VAT/SAT ratio [cm2, mean (sd)] | 1.3 (1.8) | 2.4 (1.7) | 0.002 |
Systolic blood pressure [mmHg, mean (sd)] | 122.0 (19.4) | 124.0 (16.0) | 0.558 |
Diastolic blood pressure [mmHg, mean (sd)] | 78.5 (12.1) | 79.2 (11.1) | 0.750 |
Leukocytes [109/L, mean (sd)] | 5.7 (1.7) | 6.5 (1.9) | 0.034 |
Glucose 0 min [mg/dL, mean (sd)] | 106.4 (47.1) | 119.1 (52.1) | 0.175 |
Glucose 2 h [mg/dL, mean (sd)] | 122.3 (46.3) | 138.5 (47.7) | 0.126 |
Insulin 0 min [μU/mL, mean (sd)] | 10.5 (12.8) | 10.9 (6.5) | 0.863 |
Insulin 2 h [μU/mL, mean (sd)] | 53.1 (49.2) | 105.9 (186.8) | 0.072 |
HOMA [mean (sd)] | 2.9 (3.6) | 3.2 (2.6) | 0.601 |
A1c [% mean (sd)] | 5.6 (1.2) | 6.0 (1.1) | 0.123 |
Total cholesterol [mg/dL, mean (sd)] | 213.6 (56.0) | 226.9 (57.6) | 0.216 |
LDL-cholesterol [mg/dL, mean (sd)] | 113.5 (49.2) | 123.7 (49.2) | 0.270 |
HDL-cholesterol [mg/dL, mean (sd)] | 43.9 (12.1) | 43.6 (11.3) | 0.911 |
Non-HDL cholesterol [mg/dL, mean (sd)] | 169.8 (52.0) | 183.2 (52.2) | 0.170 |
Triglycerides[mg/dL, mean (sd)] | 284.4 (191.7) | 298.9 (186.9) | 0.683 |
Apo A1 [mg/dL, mean (sd)] | 110.4 (24.0) | 111.6 (16.6) | 0.763 |
Apo B [mg/dL, mean (sd)] | 104.7 (24.4) | 104.8 (26.7) | 0.975 |
Ratio apo B/apo A1 [mean (sd)] | 0.98 (0.3) | 0.95 (0.3) | 0.604 |
Lp (a) [mg/dL, mean (sd)] | 28.9 (31.0) | 27.5 (33.5) | 0.821 |
Homocysteine [μmol/L, mean (sd)] | 9.4 (4.1) | 9.7 (3.5) | 0.701 |
CRP [mg/L, mean (sd)] | 6.6 (16.6) | 4.3 (4.7) | 0.496 |
hsCRP [mg/dL, mean (sd)] | 0.83 (1.5) | 0.34 (0.31) | 0.496 |
Lactates [mmol/L, mean (sd)] | 1.1 (0.5) | 1.3 (0.6) | 0.056 |
NT-ProBNP [pg/mL, mean (sd)] | 41.2 (74.8) | 31.6 (31.9) | 0.450 |
Fibrinogen [mg/dL, mean (sd)] | 350.8 (103.8) | 342.9 (105.9) | 0.696 |
Microalbumin [mg/L, mean (sd)] | 76.7 (196.6) | 40.6 (91.3) | 0.441 |
Uric acid [mg/L, mean (sd)] | 46.0 (14.6) | 49.8 (12.8) | 0.140 |
Carotid IMT [mm, mean (sd)] | 0.73 (0.196) | 0.82 (0.257) | 0.050 |
Metabolic Syndrome (%) | 31 (49.2%) | 27 (54.0%) | 0.705 |