Skip to main content

Table 2 In vitro activity of 14 antimicrobial agents against 881 isolates of Streptococcus pneumoniae

From: Serotype distribution and antibiotic resistance of Streptococcus pneumoniae isolates from 17 Chinese cities from 2011 to 2016

Antimicrobial agent PSSP (n = 318) PISP (n = 108) PRSP (n = 455) P
R% MIC50 MIC90 MIC range R% MIC50 MIC90 MIC range R% MIC50 MIC90 MIC range
Penicillin (oral) 0 0.016 0.032 .004–.064 0 1 1 .125–1 100 4 4 2–64-
Amoxicillin/clavulanic acid 0.3 0.016 0.032 .008–32 0 1 2 .008–2 60.7 8 16 .016–128 <  0.00001
Ceftriaxone (non meningitis) 0 0.016 0.064 .016–1 0.9 0.5 1 .016–4 40.7 2 8 .25–512
Cefuroxime oral 0.6 0.032 0.125 .016–8 45.4 2 4 .016–32 97.8 16 32 .008–512 < 0.00001
Cefaclor 2.2 1 2 .016–32 88.9 128 256 1–512- 99.8 >256 >256 2–512- < 0.00001
Vancomycin 0 0.25 0.25 .008–.5 0 0.25 0.5 .064–.5 0 0.25 0.25 .064–1
Erythromycin 89 16 >256 .016–512 96.3 32 >256 .032–512 99.3 >256 >256 .032–512 < 0.00001
Azithromycin 94.6 32 >256 .016–512 94.4 32 >256 .032–512 99.3 >256 >256 .032–512 0.135
Clarithromycin 88.3 32 >256 .016–512 80.6 32 >256 .016–512 98.6 >256 >256 .032–512 0.063
Tetracycline 84.6 32 64 .064–128 92.6 16 64 .25–64 97.1 32 64 .25–128 < 0.00001
Levofloxacin 1.3 1 1 .025–32 5.6 1 1 .25–32 2 1 1 .5–64 0.163
Moxifloxacin 0.6 0.125 0.25 .016–16 1.9 0.125 0.25 .016–8 0.7 0.125 0.25 .016–16 0.666
Trimethoprim/sulfamethoxazole 34.9 0.5 8 .032–64 60.2 4 8 .064–32 89.5 8 16 .125–128 < 0.00001
Clindamycin 74.2 128 256 .016–512 88 128 256 .016–256 97.8 256 256 .016–512 < 0.00001