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Table 6 Demographic and clinical characteristics of <5 years old children with uncomplicated falciparum malaria enrolled in study of the kinetics of the disposition of drug-attributable falls in haematocrit following artemisinin-based combination treatments

From: Factors contributing to anaemia after uncomplicated falciparum malaria in under five year-old Nigerian children ten years following adoption of artemisinin-based combination therapies as first-line antimalarials

  Treatment P value
  AA (n = 138) AL (n = 148) DHP (n = 146) ALL (n = 432)
Male/Female 78/60 74/74 82/64 234/198 0.45
Age (month)
 Mean (95% CI) 38.4 (35.6–41.2) 41 (38.5–43.6) 36.5 (33.6–39.2) 38.6 (37.1–40.2) 0.06
 Age ≤ 24 [%] 36 [26] 27 [18] 53 [36] 116 [27] 0.002
Duration of illness (day)
 Mean (95% CI) 3.6 (3.1–4.1) 3.6 (3.1–4.1) 3.4 (2.9–3.9) 3.5 (3.2–3.8) 0.79
Temperature (°C)
 Mean (95% CI) 37.9 (37.7–38.1) 37.9 (37.5–38.2) 37.8 (37.4–38.2) 37.9 (37.6–38.1) 0.76
No. with temperature
 > 37.4 °C [%] 94 [68] 104 [70] 95 [65] 293 [68] 0.63
 > 40 °C [%] 9 [6.5] 4 [3] 7 [5] 20 [5] 0.29
Haematocrit (%)
 Mean (95% CI) 31.8 (31–32.6) 31.9 (31.2–32.7) 32.3 (31.5–33) 32 (31.6–33.4) 0.67
 No. with haematocrit <30% [%] 44 [32] 40 [27] 34 [23] 114 [26] 0.54
Parasitaemia (μL−1)
 Geometric mean 17,737 22,202 20,767 20,210 0.36
 Range 2000–200,000 2004–200,000 2003–200,000 2000–200,000  
No with parasitaemia
 > 100,000 [%] 90 [65] 102 [69] 99 [68] 291 [67] 0.84
 Gametocyte carriage [%] 12 [8.7] 7 [4.7] 11 [7.5] 30 [6.9] 0.38
Fever clearance time (day)
 Mean (95% CI) 1.1 (1.1–1.2) 1.3 (1.2–1.4) 1.2 (1.1–1.3) 1.2 (1.2–1.3) 0.07
Parasite positivity
 On day 1 [%] 75 [54] 98 [66] 81 [55] 254 [59] 0.07
 On day 3 [%] 2 [1.4] 3 [2] 2 [1.4] 9 [2.1] 0.66
Parasite clearance time (day)
 Mean (95% CI) 1.8 (1.6–1.9) 1.9 (1.8–2) 1.7 (1.6–1.8) 1.8 (1.7–1.9) 0.054
  1. AA artesunate-amodiaquine, AL artemether-lumefantrine, DHP dihydroartemisinin-piperaquine, CI confidence interval