Table 6 Demographic and clinical characteristics of <5Â years old children with uncomplicated falciparum malaria enrolled in study of the kinetics of the disposition of drug-attributable falls in haematocrit following artemisinin-based combination treatments
| Â | Treatment | P value | |||
|---|---|---|---|---|---|
|  | AA (n = 138) | AL (n = 148) | DHP (n = 146) | ALL (n = 432) | |
Male/Female | 78/60 | 74/74 | 82/64 | 234/198 | 0.45 |
Age (month) | |||||
 Mean (95% CI) | 38.4 (35.6–41.2) | 41 (38.5–43.6) | 36.5 (33.6–39.2) | 38.6 (37.1–40.2) | 0.06 |
 Age ≤ 24 [%] | 36 [26] | 27 [18] | 53 [36] | 116 [27] | 0.002 |
Duration of illness (day) | |||||
 Mean (95% CI) | 3.6 (3.1–4.1) | 3.6 (3.1–4.1) | 3.4 (2.9–3.9) | 3.5 (3.2–3.8) | 0.79 |
Temperature (°C) | |||||
 Mean (95% CI) | 37.9 (37.7–38.1) | 37.9 (37.5–38.2) | 37.8 (37.4–38.2) | 37.9 (37.6–38.1) | 0.76 |
No. with temperature | |||||
 > 37.4 °C [%] | 94 [68] | 104 [70] | 95 [65] | 293 [68] | 0.63 |
 > 40 °C [%] | 9 [6.5] | 4 [3] | 7 [5] | 20 [5] | 0.29 |
Haematocrit (%) | |||||
 Mean (95% CI) | 31.8 (31–32.6) | 31.9 (31.2–32.7) | 32.3 (31.5–33) | 32 (31.6–33.4) | 0.67 |
 No. with haematocrit <30% [%] | 44 [32] | 40 [27] | 34 [23] | 114 [26] | 0.54 |
Parasitaemia (μL−1) | |||||
 Geometric mean | 17,737 | 22,202 | 20,767 | 20,210 | 0.36 |
 Range | 2000–200,000 | 2004–200,000 | 2003–200,000 | 2000–200,000 |  |
No with parasitaemia | |||||
 > 100,000 [%] | 90 [65] | 102 [69] | 99 [68] | 291 [67] | 0.84 |
 Gametocyte carriage [%] | 12 [8.7] | 7 [4.7] | 11 [7.5] | 30 [6.9] | 0.38 |
Fever clearance time (day) | |||||
 Mean (95% CI) | 1.1 (1.1–1.2) | 1.3 (1.2–1.4) | 1.2 (1.1–1.3) | 1.2 (1.2–1.3) | 0.07 |
Parasite positivity | |||||
 On day 1 [%] | 75 [54] | 98 [66] | 81 [55] | 254 [59] | 0.07 |
 On day 3 [%] | 2 [1.4] | 3 [2] | 2 [1.4] | 9 [2.1] | 0.66 |
Parasite clearance time (day) | |||||
 Mean (95% CI) | 1.8 (1.6–1.9) | 1.9 (1.8–2) | 1.7 (1.6–1.8) | 1.8 (1.7–1.9) | 0.054 |