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Table 4 Predictors of malaria-attributable fall in haematocrit (MAFH) in excess of 4% in <5 year-old children with uncomplicated falciparum malaria following artemisinin-based combination treatments

From: Factors contributing to anaemia after uncomplicated falciparum malaria in under five year-old Nigerian children ten years following adoption of artemisinin-based combination therapies as first-line antimalarials

Variable Total no. No. with MAFH >4% OR (95% CI) P value AOR (95% CI) P value
Gender
 Female 314 203 1    
 Male 380 243 1.0 (0.7–1.3) 0.91
Age (month)
 > 38 354 213 1   1  
 ≤ 38 335 228 1.4 (1.0–1.9) 0.04 2.1 (0.8–1.6) 0.53
Duration of illness (day)
 ≤ 2 200 120 1    
 > 2 274 180 1.1 (0.7–1.6) 0.78
Enrolment body temperature (°C)
 ≤ 37.4 264 173 1    
 > 37.4 429 272 0.9 (0.7–1.3) 0.63
History of fever at enrolment
 Absent 123 77 1    
 Present 571 368 1.1 (0.7–1.6) 0.78
Fever on day 1
 Absent 619 398 1    
 Present 62 38 0.9 (0.5–1.5) 0.74
Haematocrit (%)
 ≥ 30 379 170 1   1  
 < 30 315 276 8.7 (5.9–12.9) < 0.0001 9.4 (6.3–14.1) <0.0001
Parasitaemia (μL−1)
 > 50,000 171 91 1   1  
 ≤ 50,000 521 355 1.9 (1.3–2.7) 0.001 1.9 (1.3–2.9 0.002
Parasitaemia on day 1
 Absent 380 228 1   1  
 Present 314 218 1.5 (1.1–2.1) 0.01 1.6 (1.1–2.3) 0.01
Gametocytaemia (D0–7)
 Absent 621 390 1   1  
 Present 73 56 2.0 (1.1–3.4) 0.027 2.0 (1.0–3.7) 0.04
Parasite clearance time (days)
 ≤ 2 551 357 1    
 > 2 142 89 0.9 (0.6–1.3) 0.71
Fever clearance time (days)
 ≤ 2 416 261 1    
 > 2 13 11 3.3 (0.7–14.9) 0.19
Season of enrolment
 Dry (November–March) 41 23 1    
 Wet (April–October) 653 423 1.4 (0.8–2.7) 0.34
Drug treatment
 DHP 231 137 1    
 AL 229 154 1.4 (1.0–2.1) 0.1
 AA 234 155 1.3 (0.9–2.0) 0.15   
  1. OR odd ratio, AOR adjusted odd ratio, CI confidence interval, MAFH malaria-attributable fall in haematocrit, DHP dihydroartemisinin-piperaquine, AL artemether-lumefantrine, AA artesunate-amodiaquine. D0–7, day 0–7