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Table 3 Multivariate analyses of costs within the first 12 months following allogeneic HSCT for 208 consecutive patients

From: Economic burden of preemptive treatment of CMV infection after allogeneic stem cell transplantation: a retrospective study of 208 consecutive patients

Variable

Classes

Estimated value

Wald 95% Confidence Limits

P value

Model 1 included age, sex, number of CMV episodes and survival

Intercept

0

€119,539

€101,265

€141,111

<0.0001

Age (years)

< 30

1.08

0.95

1.22

0.263

30 to 50

1.07

0.97

1.17

0.1853

≥ 50

1.00

1

1

0

Sex

F

0.92

0.84

1.01

0.0647

 

M

1.00

1

1

0

Number of CMV episodes

0

0.80

0.70

0.91

0.0008

1

0.84

0.72

0.98

0.0253

≥2

1.00

1

1

0

Survival status

Dead

1.08

0.99

1.18

0.0939

Alive

1.00

1

1

0

Model 2 included age, sex, number of CMV episodes, year of transplant and type of graft. Donor/recipient match was excluded because of strong correlation with the type of graft

Intercept

0

€105,461

€86,051

€129,250

<.0001

Age (years)

< 30

1.07

0.97

1.18

0.1486

30 to 50

1.06

0.93

1.20

0.3757

≥ 50

1.00

1.00

1.00

0

Sex

Females

0.93

0.85

1.02

0.13

 

Males

1.00

1.00

1.00

.

Number of CMV episodes

0

0.78

0.68

0.90

0.0003

1

0.83

0.71

0.97

0.0201

≥2

1.00

1.00

1.00

0

Year of transplant

2008

0.83

0.71

0.97

0.0187

2009

1.01

0.87

1.18

0.8646

2010

1.05

0.91

1.22

0.509

2011

1.07

0.92

1.24

0.3775

2012

0.97

0.83

1.13

0.6772

2013

1.00

1.00

1.00

0

Type of graft

HLA-identical sibling

1.14

0.96

1.34

0.1242

Unrelated donor

1.13

0.96

1.32

0.1384

Cord Blood Unit

1.00

1.00

1.00

0

  1. We used two models to test explanatory variables that were strongly correlated (e.g age and conditioning)