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Table 2 Sources of bias

From: A comparison of the test-negative and the traditional case-control study designs for estimation of influenza vaccine effectiveness under nonrandom vaccination

Source of bias

Description

A

Vaccination affects the probability of NFARI, i.e. ρ β ≠1. This may result from virus interference [6].

B1

Health status affects the probability of NFARI, i.e. η β ≠1.

B2

Health status affects the probability of FARI, i.e. η γ ≠1.

BS

Health status affects the probability of FARI and NFARI, and the risk ratios comparing a healthy and a frail person are the same for both types of ARI, i.e. η β =η γ ≠1. This is a special case of \(B1 \bigcap B2\).

C

Vaccination affects the probability of seeking medical care for FARI, while it does not affect the probability of seeking medical care for NFARI, i.e. Ψ F ≠1. This may result from reduced severity of symptoms in vaccinated influenza patients.

D

Health status affects the probabilities of seeking medical care against FARI and NFARI, i.e. λ≠1.