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Table 3 In vitro suseptibility patterns of Candida species isolates from Colonized (C) and Infected (I) patients

From: Antifungal susceptibility testing of Candida species isolated from the immunocompromised patients admitted to ten university hospitals in Iran: comparison of colonizing and infecting isolates

Species Antifungal I
Ra
I
R%
I
GM
I
MIC90 (μg/ml)
C
Ra
C
R%
C
GM
C
MIC90
(μg/ml)
Total
ECV
(μg/ml)
Total
Wild type (%)
Total
Non-wild type (%)
Candida albicans
 AMB 0.032-16 3.3 0.052 0.25 0.032-32 0.9 0.039 0.25 0.5 ≤ 0.5(95%) > 0.5(5%)
 CAS 0.032-1 0.5 0.03 0.25 0.032-1 0.4 0.041 0.125 0.25 ≤ 0.25(98%) > 0.25(2%)
 VOR 0.032-2 6.9 0.032 0.125 0.032-16 5.4 0.035 0.064 1 ≤ 1(97%) > 1(3%)
 FLU 0.032-64 4.9 0.254 2 0.032-64 0.5 0.254 2 4 ≤ 4(96%) > 4(4%)
 POSa 0.032-8 0.044 0.25 0.032-4 0.031 0.032 0.25 ≤ 0.25(96%) > 0.25(4%)
 ITR 0.032-16 12.7 0.104 1 0.032-16 2.6 0.049 0.125 1 ≤ 1(98%) > 1(2%)
Candida tropicalis
 AMB 0.032-8 18.4 0.115 4 0.032-0.5 0 0.033 0.125 1 ≤ 1(95%) > 1(5%)
 CAS 0.032-0.5 0 0.041 0.25 0.032-4 2.9 0.046 0.125 0.5 ≤ 0.5(99%) > 0.5(1%)
 VOR 0.032-16 14.3 0.056 1 0.032-16 8.3 0.033 0.125 1 ≤ 1(96%) > 1(4%)
 FLU 0.032-64 10.5 0.361 4 0.064-64 8.8 0.302 2 4 ≤ 4(95%) > 4(5%)
 POS 0.032-0.25 0.029 0.25 0.032-16 0.035 0. 125 0.25 ≤ 0.25(95%) > 0.25(5%)
 ITR 0.032-2 13.2 0.1 1 0.032-16 0 0.078 0.5 1 ≤ 1(96%) > 1(4%)
Candida glabrata
 AMB 0.032-16 11.1 0.101 8 0.032-0.5 0 0.031 0.064 0.5 ≤ 0.5(99%) > 0.5(1%)
 CAS 0.032-8 22.2 0.086 4 0.032-0.5 9.8 0.113 0.5 0.5 ≤ 2 (96%) > 2 (4%)
 VOR 0.16-4 0 0.088 2 0.032-0.5 0 0.05 0. 25 0.5 ≤ 0.5 (96%) > 0.5(4%)
 FLU 0.25 11.1 1.17 16 0.064-16 0 0.842 4 16 ≤ 16 (98%) > 16(2%)
 POS 0.032-16 0.179 8 0.032-16 0.082 0.5 4 ≤ 4 (95%) > 4(5%)
 ITR 0.032-16 77.8 0.739 4 0.032-16 15 0.233 1 2 ≤ 2 (96%) > 2(4%)
Candida famata
 AMB 0.032-2 5 0.038 0.25 0.032-1 0 0.037 0.25 0.25 ≤ 0.25(95%) > 0.25(5%)
 CAS 0.032-16 0 0.043 0.5 0.032-0.25 0 0.035 0.25 0.25 ≤ 0.25(95%) > 0.25(5%)
 VOR 0.032-0.5 0 0.024 0.5 0.032-1 0 0.034 0.125 0.25 ≤ 0.5(98%) > 0.5(2%)
 FLU 0.064-8 0 0.278 0.5 0.032-8 0 0.268 0.5 1 ≤ 1(95%) > 1(5%)
 POS 0.032-1 0.026 0.5 0.032-0.5 0 0.031 0.064 0.5 ≤ 0.5(98%) > 0.5(2%)
 ITR 0.032-1 10 0.081 0.5 0.032-1 4.3 0.062 0.5 0.5 ≤ 0.5(98%) > 0.5(2%)
Candida parapsilopsis
 AMB 0.032-0.5 0 0.023 0.032 0.032-0.25 0 0.027 0.032 0.25 ≤ 0.25(95%) > 0.25(5%)
 CAS 0.032-0.25 0 0.037 4 0.032-4 0 0.283 0.125 0.125 ≤ 4(98%) > 4(2%)
 VOR 0.032-0.032 0 0.017 0.032 0.032-0.25 0 0.025 0.032 0.032 ≤ 0.032(96%) > 0.032(4%)
 FLU 0.064-8 2.9 0.402 4 0.064-2 0 0.298 2 2 ≤ 2(100%) > 2(00%)
 POS 0.032-0.032 0.017 0.032 0.032-0.5 0.03 0.032 0.032 ≤ 0.032(96%) > 0.032(4%)
 ITR 0.032-0.5 0 0.0102 0.5 0.032-0.032 0 0.02 0.125 0.5 ≤ 0.5(100%) > 0.5(00%)
Candida kefyr
 AMB 0.032-1 0 0.045 1 0.032-1 0 0.03 0.064 1 ≤ 1(99%) > 1(1%)
 CAS 0.032-0.125 0 0.028 0.25 0.032-2 0 0.031 0.25 0.125 ≤ 0.25(95%) > 0.25(5%)
 VOR 0.032-0.032 0 0.018 0.032 0.032-0.125 0 0.021 0.032 0.032 ≤ 0.032(96%) > 0.032(4%)
 FLU 0.25-0.5 0 0.397 1 0.064-2 0 0.185 0.5 1 ≤ 1(96%) > 1(4%)
 POS 0.032-0.032 0.018 0.032 0.032-0.125 0.021 0.032 0.032 ≤ 0.032(96%) > 0.032(4%)
 ITR 0.032-0.125 0 0.032 0.125 0.032-0.25 0 0.037 0.125 0.125 ≤ 0.125(96%) > 0.125(96%)
Candida krusei b
 AMB 0.032-8 40 1.004 8 0.032-4 40 0.386 4 4 ≤ 4(95%) > 4(5%)
 CAS 0.032-2 30 0.2 2 0.032-0.5 0 0.092 0.25 2 ≤ 2(99%) > 2(1%)
 VOR 0.032-16 20 0.284 2 0.032-16 7.7 0.235 0.5 2 ≤ 2(95%) > 2(5%)
 FLU 2-64 17.9 64 0.25-64 6.817 64 64 ≤ 64(95%) > 64(5%)
 POS 0.032-0.5 0.126 0.5 0.032-16 0.214 0.5 0.5 ≤ 0.5(95%) > 0.5(5%)
 ITR 0.064-1 33.3 0.2 2 0.064-16 15.4 0.346 1 2 ≤ 2(95%) > 2(5%)
Other Candida spp.c
 AMB 0.032-0.032 0 0.032 0.032 0.032-1 0 0.032 0.064 0.064 ≤ 0.064(95%) > 0.064(95%)
 CAS 0.032-0.064 0 0.021 0.064 0.032-1 0 0.064 0.064 0.064 ≤ 0.064(95%) > 0.064(95%)
 VOR 0.032-0.032 0 0.032 0.032 0.032-0.125 0 0.026 0.032 0.125 ≤ 0.125(100%) > 0.125(100%)
 FLU 0.0125-4 0 0.33 4 0.064-8 0 0.227 0.5 4 ≤ 4(95%) > 4(95%)
 POS 0.032-0.032 0 0.032 0.032 0.032-0.064 0 0.023 0.032 0.032 ≤ 0.032(95%) > 0.032(95%)
 ITR 0.032-0.0125 0 0.024 0.125 0.032-0. 25 0 0.042 0.25 0.25 ≤ 0.25(100%) > 0.25(100%)
  1. Ra Range, MIC minimum inhibitory concentration, R resistant, MIC 90 Lowest concentration at which 90% of the isolates are inhibited
  2. aPosaconazole has no breakpoint in new CLSI
  3. bIsolates of C. krusei are considered resistant to fluconazole, irrespective of the MIC
  4. cOthers: include; C. intermedia, C. dubliniensis, C. lusitaniae and M. guilliermondii (C. guilliermondii)