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Table 1 Demographic and clinical variables of MDR-TB patients registered in SITE-TB, Brazil, 2007–2013

From: Treatment outcomes of MDR-tuberculosis patients in Brazil: a retrospective cohort analysis

Variable Included in study
(1972)
Excluded from study
(2057)
P- value
Sex    0.06
 Female 662 (34%) 749 (36%)  
 Male 1310 (66%) 1308 (64%)  
Age (mean) 39.5 (SD 13.5) 39.6 (SD 13.4) 0.89
Regimen    <0.01
 Individualized 448 (23%) 562 (27%)  
 Standardized 1524 (77%) 1466 (72%)  
 Unknown 0 (0%) 29 (1%)  
Ethnical group    
 Afro-Brazilian 1213 (61%) 1217 (59%) 0.04
 Indigenous 10 (1%) 6 (1%)  
 Caucasian 728 (37%) 795 (39%)  
 Other 21 (1%) 39 (1%)  
TB Site    0.80
 Pulmonary 1916 (97%) 1994 (97%)  
 Extra-pulmonary 21 (1%) 21 (1%)  
 Both 35 (2%) 42 (2%)  
AFB at baseline    
 Negative 273 (14%) 293 (14%) <0.01
 Positive 1650 (84%) 1647 (80%)  
 Unknown 49 (2%) 117 (6%)  
HIV    <0.01
 Positive 180 (9%) 201 (10%)  
 Negative 1721 (87%) 1697 (83%)  
 Unknown 71 (4%) 159 (7%)  
Cavity    0.20
 Yes 1554 (79%) 1665 (81%)  
 No 396 (20%) 371 (18%)  
 Unknown 22 (1%) 21 (1%)  
Bilateral disease    <0.01
 Yes 1283 (65%) 1456 (70%)  
 No 667 (34%) 580 (29%)  
 Unknown 22 (1%) 21 (1%)  
Smoking    <0.01
 Yes 156 (8%) 231 (11%)  
 No/unknown 1816 (92%) 1826 (89%)  
Alcohol use    0.02
 Yes 350 (18%) 424 (21%)  
 No/unknown 1622 (82%) 1633 (79%)  
Diabetes    0.40
 Yes 227 (12%) 218 (11%)  
 No/unknown 1745 (88%) 1839 (89%)  
DOT    <0.01
 Yes 1558 (79%) 1472 (72%)  
 No/unknown 414 (21%) 585 (28%)  
Macro-region    0.08
 North 223 (11%) 204 (9%)  
 North-eastern 580 (29%) 560 (28%)  
 Centre-west 51 (3%) 45 (2%)  
 South-eastern 856 (44%) 981 (48%)  
 South 262 (13%) 267 (13%)  
First DR-TB episode    <0.01
 Yes 1643 (84%) 1510 (73%)  
 No 284 (14%) 456 (23%)  
 Unknown 45 (2%) 91 (4%)  
Outcome    <0.01
 Cure* 686 (35%) 444 (22%)  
 Complete treatment* 489 (25%) 430 (21%)  
 Failure 183 (9%) 215 (10%)  
 Loss to follow-up 389 (20%) 344 (17%)  
 Death 211 (9%) 261 (13%)  
 Unknown 7 (1%) 30 (1%)  
 Transfer 0 (0%) 1 (0%)  
 On treatment 7 (1%) 332 (16%)  
Six month culture conversion    <0.01
 Yes 879 (45%) 795 (39%)  
 No 206 (10%) 210 (10%)  
 Unknown 887 (45%) 1052 (51%)  
  1. Abbreviation: DR-TB drug-resistant tuberculosis, AFB acid fast bacilli, SD standard deviation, DOT directly observed treatment
  2. *Among included patients 10 had relapse episodes of MDR-TB