Table 1 Demographic and clinical variables of MDR-TB patients registered in SITE-TB, Brazil, 2007–2013
From: Treatment outcomes of MDR-tuberculosis patients in Brazil: a retrospective cohort analysis
Variable | Included in study (1972) | Excluded from study (2057) | P- value |
|---|---|---|---|
Sex | 0.06 | ||
Female | 662 (34%) | 749 (36%) | |
Male | 1310 (66%) | 1308 (64%) | |
Age (mean) | 39.5 (SD 13.5) | 39.6 (SD 13.4) | 0.89 |
Regimen | <0.01 | ||
Individualized | 448 (23%) | 562 (27%) | |
Standardized | 1524 (77%) | 1466 (72%) | |
Unknown | 0 (0%) | 29 (1%) | |
Ethnical group | |||
Afro-Brazilian | 1213 (61%) | 1217 (59%) | 0.04 |
Indigenous | 10 (1%) | 6 (1%) | |
Caucasian | 728 (37%) | 795 (39%) | |
Other | 21 (1%) | 39 (1%) | |
TB Site | 0.80 | ||
Pulmonary | 1916 (97%) | 1994 (97%) | |
Extra-pulmonary | 21 (1%) | 21 (1%) | |
Both | 35 (2%) | 42 (2%) | |
AFB at baseline | |||
Negative | 273 (14%) | 293 (14%) | <0.01 |
Positive | 1650 (84%) | 1647 (80%) | |
Unknown | 49 (2%) | 117 (6%) | |
HIV | <0.01 | ||
Positive | 180 (9%) | 201 (10%) | |
Negative | 1721 (87%) | 1697 (83%) | |
Unknown | 71 (4%) | 159 (7%) | |
Cavity | 0.20 | ||
Yes | 1554 (79%) | 1665 (81%) | |
No | 396 (20%) | 371 (18%) | |
Unknown | 22 (1%) | 21 (1%) | |
Bilateral disease | <0.01 | ||
Yes | 1283 (65%) | 1456 (70%) | |
No | 667 (34%) | 580 (29%) | |
Unknown | 22 (1%) | 21 (1%) | |
Smoking | <0.01 | ||
Yes | 156 (8%) | 231 (11%) | |
No/unknown | 1816 (92%) | 1826 (89%) | |
Alcohol use | 0.02 | ||
Yes | 350 (18%) | 424 (21%) | |
No/unknown | 1622 (82%) | 1633 (79%) | |
Diabetes | 0.40 | ||
Yes | 227 (12%) | 218 (11%) | |
No/unknown | 1745 (88%) | 1839 (89%) | |
DOT | <0.01 | ||
Yes | 1558 (79%) | 1472 (72%) | |
No/unknown | 414 (21%) | 585 (28%) | |
Macro-region | 0.08 | ||
North | 223 (11%) | 204 (9%) | |
North-eastern | 580 (29%) | 560 (28%) | |
Centre-west | 51 (3%) | 45 (2%) | |
South-eastern | 856 (44%) | 981 (48%) | |
South | 262 (13%) | 267 (13%) | |
First DR-TB episode | <0.01 | ||
Yes | 1643 (84%) | 1510 (73%) | |
No | 284 (14%) | 456 (23%) | |
Unknown | 45 (2%) | 91 (4%) | |
Outcome | <0.01 | ||
Cure* | 686 (35%) | 444 (22%) | |
Complete treatment* | 489 (25%) | 430 (21%) | |
Failure | 183 (9%) | 215 (10%) | |
Loss to follow-up | 389 (20%) | 344 (17%) | |
Death | 211 (9%) | 261 (13%) | |
Unknown | 7 (1%) | 30 (1%) | |
Transfer | 0 (0%) | 1 (0%) | |
On treatment | 7 (1%) | 332 (16%) | |
Six month culture conversion | <0.01 | ||
Yes | 879 (45%) | 795 (39%) | |
No | 206 (10%) | 210 (10%) | |
Unknown | 887 (45%) | 1052 (51%) |