|
Characteristic
|
Exposed to abacavir (n = 8530)
|
Exposed to other ARV agents (reference group) (n = 64,203)
|
|---|
|
Age, median (IQR)
|
48 (43–54)
|
46 (39–52)
|
|
Male
|
6889 (80.76)
|
52,402 (81.62)
|
|
Region
|
|
East
|
2057 (24.11)
|
15,336 (23.89)
|
|
Mid-West
|
1370 (16.06)
|
12,104 (18.85)
|
|
South
|
3986 (46.73)
|
29,179 (45.45)
|
|
West
|
1117 (13.09)
|
7584 (11.81)
|
|
Year of ART initiation in the database
|
|
2009
|
3590 (42.09)
|
20,440 (31.84)
|
|
2010
|
1120 (13.13)
|
8578 (13.36)
|
|
2011
|
1147 (13.45)
|
9121 (14.21)
|
|
2012
|
801 (9.39)
|
7824 (12.19)
|
|
2013
|
643 (7.54)
|
7259 (11.39)
|
|
2014
|
1229 (14.41)
|
10,981 (17.10)
|
|
Ever substance abuse
|
1290 (15.12)
|
11,837 (18.44)
|
|
Ever alcohol abuse
|
273 (3.20)
|
2750 (4.28)
|
|
Ever tobacco use/smoking
|
1198 (14.04)
|
10,385 (16.18)
|
|
Body mass index > 24.9
|
116 (1.36)
|
1130 (1.76)
|
|
Essential hypertension
|
766 (8.98)
|
5026 (7.83)
|
|
Diabetes mellitus
|
366 (4.29)
|
2049 (3.19)
|
|
Chronic Kidney Disease
|
265 (3.11)
|
492 (0.77)
|
|
Dyslipidemia
|
820 (9.61)
|
5552 (8.65)
|
|
Lipodystrophy
|
36 (0.42)
|
129 (0.20)
|
|
Pre-existing heart diseasea
|
242 (2.84)
|
1768 (2.75)
|
|
Receipt of medications for heart diseaseb
|
819 (9.60)
|
4816 (7.50)
|
|
History of stroke
|
25 (0.29)
|
160 (0.25)
|
|
Symptomatic HIV disease
|
2313 (27.12)
|
18,839 (29.34)
|
|
Hepatitis B
|
69 (0.81)
|
612 (0.95)
|
|
Hepatitis C
|
141 (1.65)
|
896 (1.40)
|
|
History of cancer
|
438 (5.13)
|
4152 (6.47)
|
- All reported as N (%) unless otherwise stated
-
aPrior myocardial infarction, heart failure, cardiac dysrhythmias, and atherosclerosis
-
bAspirin, beta-blocker, statins, angiotensin converting enzyme inhibitor, angiotensin receptor blocker, calcium channel blocker
