Table 1 Baseline characteristics of persons living with HIV in the US receiving antiretroviral agents, stratified by exposure to abacavir, in the IMS PharMetric Plus claims database from October 1, 2009 through December 31, 2014
Characteristic | Exposed to abacavir (n = 8530) | Exposed to other ARV agents (reference group) (n = 64,203) |
|---|---|---|
Age, median (IQR) | 48 (43–54) | 46 (39–52) |
Male | 6889 (80.76) | 52,402 (81.62) |
Region | ||
 East | 2057 (24.11) | 15,336 (23.89) |
 Mid-West | 1370 (16.06) | 12,104 (18.85) |
 South | 3986 (46.73) | 29,179 (45.45) |
 West | 1117 (13.09) | 7584 (11.81) |
Year of ART initiation in the database | ||
 2009 | 3590 (42.09) | 20,440 (31.84) |
 2010 | 1120 (13.13) | 8578 (13.36) |
 2011 | 1147 (13.45) | 9121 (14.21) |
 2012 | 801 (9.39) | 7824 (12.19) |
 2013 | 643 (7.54) | 7259 (11.39) |
 2014 | 1229 (14.41) | 10,981 (17.10) |
Ever substance abuse | 1290 (15.12) | 11,837 (18.44) |
Ever alcohol abuse | 273 (3.20) | 2750 (4.28) |
Ever tobacco use/smoking | 1198 (14.04) | 10,385 (16.18) |
Body mass index > 24.9 | 116 (1.36) | 1130 (1.76) |
Essential hypertension | 766 (8.98) | 5026 (7.83) |
Diabetes mellitus | 366 (4.29) | 2049 (3.19) |
Chronic Kidney Disease | 265 (3.11) | 492 (0.77) |
Dyslipidemia | 820 (9.61) | 5552 (8.65) |
Lipodystrophy | 36 (0.42) | 129 (0.20) |
Pre-existing heart diseasea | 242 (2.84) | 1768 (2.75) |
Receipt of medications for heart diseaseb | 819 (9.60) | 4816 (7.50) |
History of stroke | 25 (0.29) | 160 (0.25) |
Symptomatic HIV disease | 2313 (27.12) | 18,839 (29.34) |
Hepatitis B | 69 (0.81) | 612 (0.95) |
Hepatitis C | 141 (1.65) | 896 (1.40) |
History of cancer | 438 (5.13) | 4152 (6.47) |