Table 6 Distrubition by age of allele and genotype frequencies of the rs1050504 and rs2228505 polymorphisms between pulmonary tuberculosis patients and healthy controls
|  | ≤ 29 years | 30–49 years | ≥ 50 years | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | PTB (%) | Controls (%) | p-Value | OR (95% CI) | PTB (%) | Controls (%) | p-Value | OR (95% CI) | PTB (%) | Controls (%) | p-Value | OR (95%CI) |
rs1050504[C/T] | ||||||||||||
Genotypes | n = 60 | n = 44 |  |  | n = 49 | n = 81 |  |  | n = 13 | n = 16 |  |  |
  CC | 31(51,7) | 29 (65,9) | 0,14 | 0,55(0,24–1,27) | 28 (57,1) | 43 (53,1) | 0,65 | 1,17 (0,57–2,4) | 8 (61,5) | 9 (56,2) | 0,91 | 1,08 (2,23–4,94) |
  CT | 27 (45) | 12 (27,3) | 0,06 | 2,18 (0,94–5,03) | 18 (36,8) | 20 (24,7) | 0,14 | 1,77 (0,82–3,82) | 5 (38,5) | 6 (37,5) | 0,82 | 1,19 (0,25–5,49) |
  TT | 2 (3,3) | 3 (6,8) | 0,41 | 0,47 (0,07–2,94) | 3 (6,1) | 18 (22,2) | 0,01* | 0,22 (0,06–0,82) | 0 | 1 (6,3) | 0,37 | ND |
Alleles | ||||||||||||
  C | 89 (74,2) | 70 (79,5) | 0,36 | 0,73 (0,38–1,42) | 74 (75,5) | 106 (65,4) | 0,08 | 1,62 (0,92–2,85) | 19 (79,2) | 24 (75) | 0,71 | 1,26 (0,35–4,5) |
  T | 31 (25,8) | 18 (20,5) |  |  | 24 (24,5) | 56 (34,6) |  |  | 5 (20,8) | 8 (25) |  |  |
rs2228505[T/C] | ||||||||||||
Genotypes | n = 64 | n = 40 |  |  | n = 52 | n = 62 |  |  | n = 12 | n = 15 |  |  |
  TT | 47 (73,5) | 31 (77,5) | 0,64 | 0,80 (0,31–2,02) | 38 (73,1) | 52 (83,9) | 0,15 | 0,52 (0,20–1,30) | 10 (83,3) | 12 (80) | 0,82 | 1,25 (0,17–9,01) |
  CT | 15 (23,4) | 9 (22,5) | 0,91 | 1,05 (0,41–2,7) | 13 (25) | 10 (16,1) | 0,23 | 1,73 (0,68–4,36) | 2 (16,7) | 3 (20) | 0,82 | 0,8 (0,11–5,77) |
  CC | 2 (3,1) | 0 | 0,25 | ND | 1 (1,9) | 0 | 0,27 | ND | 0 | 0 | ND | ND |
Alleles | ||||||||||||
  T | 109 (85,2) | 71 (88,7) | 0,46 | 0,72 (0,31–1,69) | 89 (85,6) | 114 (92) | 0,12 | 0,52 (0,22–1,21) | 22 (91,7) | 27 (90) | 0,83 | 1,22 (0,18–7,97) |
  C | 19 (14,8) | 9 (11,3) |  |  | 15 (14,4) | 10 (8) |  |  | 2 (8,3) | 3 (10) |  |  |