Table 5 Distribution by sex of allele and genotype frequencies of the rs1050504 and rs2228505 polymorphisms between pulmonary tuberculosis patients and healthy controls
| Â | PTB patients | Controls | TB male vs healthy male | TB female vs healthy female | ||||
|---|---|---|---|---|---|---|---|---|
| Â | M (%) | F (%) | M (%) | F (%) | p-value | OR (95% CI) | p-value | OR (95% CI) |
rs1050504 [C/T] | ||||||||
 Genotypes | n = 90 | n = 32 | n = 101 | n = 40 |  |  |  |  |
  CC | 48 (53,3) | 18 (56,3) | 56 (55.5) | 25 (62.5) | 0,76 | 0,91 (0,51–1,62) | 0,59 | 0,77 (0,29–1,98) |
  CT | 38 (42,2) | 13 (40,6) | 26 (25.7) | 12 (30) | 0,01* | 2,1 (1,14–3,88) | 0,34 | 1,59 (0,6–4,24) |
  TT | 4 (4,5) | 1 (3,1) | 19 (18.8) | 3 (7.5) | 0,002* | 0,2 (0,06–0,62) | 0,42 | 0,39 (0,03–4,02) |
Alleles | ||||||||
  C | 134(74,4) | 49 (76,6) | 138 (68,3) | 62 (77,5) | 0,16 | 1,37(0,87–2,14) | 0,89 | 0,94 (0,43–2,07) |
  T | 46 (25,6) | 15 (23,4) | 64 (31,7) | 18 (22,5) | ||||
rs2228505 [T/C] | ||||||||
 Genotypes | n = 94 | n = 34 | n = 78 | n = 40 |  |  |  |  |
  TT | 64 (68,1) | 31 (91,2) | 62 (79,5) | 34 (85) | 0,09 | 0,55 (0,27–1,1) | 0,41 | 1,82 (0,41–7,9) |
  CT | 27 (28,7) | 3 (8,8) | 16 (20,5) | 6 (15) | 0,21 | 1,56 (0,76–3,17) | 0,41 | 0,54 (0,12–2,38) |
  CC | 3 (3,2) | 0 | 0 | 0 | 0,11 | ND | ND | ND |
Alleles | ||||||||
  T | 155(82,4) | 65 (95,6) | 140 (89,7) | 74 (92,5) | 0,53 | 0,53 (0,28–1,01) | 0,43 | 1,75 (0,42–7,3) |
  C | 33 (17,6) | 3 (4,4) | 16 (10,3) | 6 (7,5) |  | |||