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Table 2 Summary of innovative technologies to provide more affordable and simplified HBV and HCV testing and treatment monitoring

From: The future of viral hepatitis testing: innovations in testing technologies and approaches

Area of Innovation Technology or strategy Primary testing target Potential future testing target Potential impact
1. Simplification of algorithms • Elimination of need for genotyping with access to pan-genotypic DAAs, and only a single time point (SVR12) for assessment of cure HCV   Reduce costs; Improve uptake
2. Sampling approaches • Dried blood spots (DBS)
• Oral fluid
• HCV
• HCV
  Increase access and coverage, reaching key and target populations
3. Innovative testing approaches • Self-testing
• Combo integrated multi-disease tests
• Integrated multidisease testing platforms (centralised and decentralised)
• HCV
• HCV
• HCV
• HBV
• HBV
Increase awareness, reduce stigma; Maximise programme synergies and reduce costs. Improve access to testing,
4. New technologies • Point-of-care (POC) NAT
• HCV core antigen test (as laboratory based assay and in future as POC)
• HCV
• HCV
• HBV Increase access to confirmation of viraemia
5. Health system improvements • Integrated testing and service decentralization
• Data connectivity
• Sample chain and supply management
• HCV • HBV Improve timely receipt of results and linkage to care; improve supply chain management;
Optimize use of current infrastructure, sample workflow