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Table 5 WHO recommendations for viral hepatitis testing [5]

From: One or two serological assay testing strategy for diagnosis of HBV and HCV infection? The use of predictive modelling

Testing strategies for diagnosis of chronic HBV infection
- In settings or populations with an HBsAg seroprevalence ≥0.4%, a single serological assay for detection of HBsAg is recommended, prior to further evaluation for HBV DNA and staging of liver disease.
- In settings or populations with an HBsAg seroprevalence <0.4% confirmation of HBsAg positivity on the same immunoassay with a neutralization step or a second different assay for detection of HBsAg may be considered.
Testing strategy for detection of antibodies to HCV
- In adults and children older than 18 months, a single serological assay for initial detection of exposure to hepatitis C is recommended prior to supplementary nucleic acid testing (NAT) or HCV core antigen for evidence of current chronic HCV infection.