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Table 5 Summary pooled diagnostic accuracy of rapid HBsAg assays stratified by study, patient, index and reference tests

From: Diagnostic accuracy of tests to detect hepatitis B surface antigen: a systematic review of the literature and meta-analysis

 

Subgroup

Studies, n

Sample size, n

Points, n

Pooled clinical accuracy (95% CI)

Likelihood ratios (95% CI)

Sensitivity

Specificity

Positive

Negative

Study

Pre 2005

9

8854 (206–2754)

19

96.9 (96.0–97.7)

99.7 (99.6–99.8)

265.5 (106.1–664.5)

0.06 (0.03–0.10)

 

Post 2005

21

14,862 (25–3956)

44

86.4 (85.2–87.5)

99.4 (99.2–99.5)

84.6 (43.6–164.6)

0.13 (0.09–0.18)

 

HIV-positive

5

2596 (75–973)

6

72.3 (67.9–76.4)

99.8 (99.5–99.9)

192.6 (77.4–497.2)

0.29 (0.22–0.38)

Specimen type

Whole blood

8

6889 (25–3956)

11

91.7 (89.1–93.9)

99.9 (99.8–99.9)

346.6 (157.6–762.4)

0.09 (0.06–0.14)

Index test

Determine

10

7730 (75–2472)

12

90.8 (88.9–92.4)

99.1 (98.9–99.4)

239 (17.1–33,300)

0.077 (0.035–0.168)

 

VIKIA

3

5242 (476–3928)

3

82.5 (77.5–86.7)

99.9 (99.8–100)

1070 (376–3060)

0.108 (0.026–0.458)

 

BinaxNOW

3

3542 (137–2463)

6

97.6 (96.2–98.6)

100 (99.7–100)

221 (36.1–1350)

0.045 (0.016–0.128)

 

Serodia

3

1040 (250–462)

3

95.8 (93.4–97.5)

99.8 (99.1–100)

285 (71.4–1140)

0.045 (0.029–0.069)

Reference test

CMIA

5

3521 (227–1768)

9

80.4 (77.9–82.6)

99.0 (99.6–99.3)

58.5 (31.3–109)

0.141 (0.074–0.268)