| Subgroup | Studies, n | Sample size, n | Points, n | Pooled clinical accuracy (95% CI) | Likelihood ratios (95% CI) | ||
---|---|---|---|---|---|---|---|---|
Sensitivity | Specificity | Positive | Negative | |||||
Study | Pre 2005 | 9 | 8854 (206–2754) | 19 | 96.9 (96.0–97.7) | 99.7 (99.6–99.8) | 265.5 (106.1–664.5) | 0.06 (0.03–0.10) |
 | Post 2005 | 21 | 14,862 (25–3956) | 44 | 86.4 (85.2–87.5) | 99.4 (99.2–99.5) | 84.6 (43.6–164.6) | 0.13 (0.09–0.18) |
 | HIV-positive | 5 | 2596 (75–973) | 6 | 72.3 (67.9–76.4) | 99.8 (99.5–99.9) | 192.6 (77.4–497.2) | 0.29 (0.22–0.38) |
Specimen type | Whole blood | 8 | 6889 (25–3956) | 11 | 91.7 (89.1–93.9) | 99.9 (99.8–99.9) | 346.6 (157.6–762.4) | 0.09 (0.06–0.14) |
Index test | Determine | 10 | 7730 (75–2472) | 12 | 90.8 (88.9–92.4) | 99.1 (98.9–99.4) | 239 (17.1–33,300) | 0.077 (0.035–0.168) |
 | VIKIA | 3 | 5242 (476–3928) | 3 | 82.5 (77.5–86.7) | 99.9 (99.8–100) | 1070 (376–3060) | 0.108 (0.026–0.458) |
 | BinaxNOW | 3 | 3542 (137–2463) | 6 | 97.6 (96.2–98.6) | 100 (99.7–100) | 221 (36.1–1350) | 0.045 (0.016–0.128) |
 | Serodia | 3 | 1040 (250–462) | 3 | 95.8 (93.4–97.5) | 99.8 (99.1–100) | 285 (71.4–1140) | 0.045 (0.029–0.069) |
Reference test | CMIA | 5 | 3521 (227–1768) | 9 | 80.4 (77.9–82.6) | 99.0 (99.6–99.3) | 58.5 (31.3–109) | 0.141 (0.074–0.268) |