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Table 5 Summary pooled diagnostic accuracy of rapid HBsAg assays stratified by study, patient, index and reference tests

From: Diagnostic accuracy of tests to detect hepatitis B surface antigen: a systematic review of the literature and meta-analysis

  Subgroup Studies, n Sample size, n Points, n Pooled clinical accuracy (95% CI) Likelihood ratios (95% CI)
Sensitivity Specificity Positive Negative
Study Pre 2005 9 8854 (206–2754) 19 96.9 (96.0–97.7) 99.7 (99.6–99.8) 265.5 (106.1–664.5) 0.06 (0.03–0.10)
  Post 2005 21 14,862 (25–3956) 44 86.4 (85.2–87.5) 99.4 (99.2–99.5) 84.6 (43.6–164.6) 0.13 (0.09–0.18)
  HIV-positive 5 2596 (75–973) 6 72.3 (67.9–76.4) 99.8 (99.5–99.9) 192.6 (77.4–497.2) 0.29 (0.22–0.38)
Specimen type Whole blood 8 6889 (25–3956) 11 91.7 (89.1–93.9) 99.9 (99.8–99.9) 346.6 (157.6–762.4) 0.09 (0.06–0.14)
Index test Determine 10 7730 (75–2472) 12 90.8 (88.9–92.4) 99.1 (98.9–99.4) 239 (17.1–33,300) 0.077 (0.035–0.168)
  VIKIA 3 5242 (476–3928) 3 82.5 (77.5–86.7) 99.9 (99.8–100) 1070 (376–3060) 0.108 (0.026–0.458)
  BinaxNOW 3 3542 (137–2463) 6 97.6 (96.2–98.6) 100 (99.7–100) 221 (36.1–1350) 0.045 (0.016–0.128)
  Serodia 3 1040 (250–462) 3 95.8 (93.4–97.5) 99.8 (99.1–100) 285 (71.4–1140) 0.045 (0.029–0.069)
Reference test CMIA 5 3521 (227–1768) 9 80.4 (77.9–82.6) 99.0 (99.6–99.3) 58.5 (31.3–109) 0.141 (0.074–0.268)