Table 4 Summary pooled diagnostic accuracy of HBsAg assays using EIA reference standards
Index test | HIV status | Studies, n | Sample size (range), n | Data points, n | Pooled clinical accuracy (95% CI) | Likelihood ratios (95% CI) | ||
|---|---|---|---|---|---|---|---|---|
Sensitivity | Specificity | Positive | Negative | |||||
RDT | NA | 30 | 23,716 (25–3928) | 63 | 90.0 (89.1–90.8) | 99.5 (99.4–99.5) | 117.5 (67.7–204.1) | 0.10 (0.07–0.14) |
HIV-positive | 5 | 2596 (75–973) | 6 | 72.3 (67.9–76.4) | 99.8 (99.5–99.9) | 192.6 (77.4–497.2) | 0.29 (0.22–0.38) | |
EIA | NA | 5 | 1825 (119–838) | 8 | 88.9 (87.0–90.6) | 98.4 (97.8–98.8) | 46.8 (12.9–170.0) | 0.04 (0.01–0.13) |
HIV-positive | 1 | 838 | 3 | 97.9 (96.0–99.0) | 99.4 (99.0–99.7) | 167.3 (95.1–294.1) | 0.02 (0.01–0.04) | |