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Table 4 Summary pooled diagnostic accuracy of HBsAg assays using EIA reference standards

From: Diagnostic accuracy of tests to detect hepatitis B surface antigen: a systematic review of the literature and meta-analysis

Index test HIV status Studies, n Sample size (range), n Data points, n Pooled clinical accuracy (95% CI) Likelihood ratios (95% CI)
Sensitivity Specificity Positive Negative
RDT NA 30 23,716 (25–3928) 63 90.0 (89.1–90.8) 99.5 (99.4–99.5) 117.5 (67.7–204.1) 0.10 (0.07–0.14)
HIV-positive 5 2596 (75–973) 6 72.3 (67.9–76.4) 99.8 (99.5–99.9) 192.6 (77.4–497.2) 0.29 (0.22–0.38)
EIA NA 5 1825 (119–838) 8 88.9 (87.0–90.6) 98.4 (97.8–98.8) 46.8 (12.9–170.0) 0.04 (0.01–0.13)
HIV-positive 1 838 3 97.9 (96.0–99.0) 99.4 (99.0–99.7) 167.3 (95.1–294.1) 0.02 (0.01–0.04)