Skip to main content

Table 3 Study Characteristics of rapid-diagnostic tests (RDTs) or laboratory-based immunoassays (EIA) against nucleic-acid test reference standards [RDT/EIA vs NAT]

From: Diagnostic accuracy of tests to detect hepatitis B surface antigen: a systematic review of the literature and meta-analysis

Study [author, year] Location [country, city] Sample size, n Study design Setting Sample Test under evaluation [type, brand] Reference test [type, brand]
Ansari, 2007 [51] Iran, Urumieh 240 CC Hospital patients S RDT, ACON
RDT, Atlas
RDT, Blue Cross
RDT, Cortez
RDT, DIMA
RDT, Intec
qPCR
Nna, 2014 [52] Nigeria 113 CS Blood donors (repeat) – all were HIV negative P RDT, ACON Nested PCR; qPCR for positive
Seremba, 2010 [53] Uganda 157 CS - CSQ Hospital patients (emergency medical ward), including HIV+ (83) and HIV- (74). S RDT, Cortez
EIA, ADVIA
PCR
Khadem-Ansari, 2014 [54] Iran, Urumieh 350 CS – CSQ? Hospital patients - referred as? HBV S ChLIA, Liaison Rt-PCR
Lukhwareni, 2009 [56] South Africa 192 CC HIV cohort - pre ART S ChLIA, Elecsys qPCR
Mphahlele, 2006 [57] South Africa 295 CC Hospital patients, HIV+ (167) and HIV- (128) S EIA, AxSYM Nested PCR
Olinger, 2007 [55] Nigeria, Ibadan 200 CS Hospital patients - Liver disease, HIV S MEIA, AxSYM v2
ChLIA, Elecsys
ELFA, VIDAS Ultra
rtPCR and nested PCR
  1. CC case control, ChLIA chemiluminescent immunoassay, CMIA chemiluminescent microparticle enzyme immunoassay, CS cross-sectional, CSQ consecutive patients, ECLIA electrochemiluminescent immunoassay, EIA enzyme immunoassay, ELFA enzyme linked fluorescent assay, ELISA enzyme linked immunosorbent assay, MEIA microparticle enzyme immunoassay, qPCR quantitative PCR, RDT rapid diagnostic test, rtPCR realtime PCR