Prevalence and molecular characterization of pyrazinamide resistance among multidrug-resistant Mycobacterium tuberculosis isolates from Southern China

Table 4 Performance of pncA mutations for predicting PZA susceptibility

Mutation in pncA	PZA susceptibility^a		Total	Sensitivity (95% CI, %)	Specificity (95% CI, %)	PPV (95% CI, %)	NPV (95% CI, %)
Mutation in pncA	R	S	Total	Sensitivity (95% CI, %)	Specificity (95% CI, %)	PPV (95% CI, %)	NPV (95% CI, %)
Yes	73	4	77	88.0 (80.9–95.0)	92.0 (84.5–99.5)	94.8 (89.8–99.8)	82.1 (72.1–92.2)
No	10	46	56
Total	83	50	133

^a R, resistant, S susceptible, PPV positive predictive value, NPV negative predictive value, CI confidence interval

ISSN: 1471-2334