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Table 2 Mutations of PZA-resistant MDR-TB isolates within pncA

From: Prevalence and molecular characterization of pyrazinamide resistance among multidrug-resistant Mycobacterium tuberculosis isolates from Southern China

Locus

Position of nucleotide

Nucleotide substitution

Position of amino acid

Amino acid substitution

No. of isolates

pncA

−11

TAT → TGT

−4

Tyr → Cys

4

 

2

ATG → ACG

1

Met → Thr

1

 

20

GTC → GGC

7

Val → Gly

2

 

24

GAC → GAG

8

Asp → Glu

1

 

28

CAG → TAG

10

Gln → Stop

1

 

35

GAC → GCC

12

Asp → Ala

2

 

37

TTC → GTC

13

Phe → Val

1

 

40

TGC → CGC

14

Cys → Arg

2

 

40

TGC → CGC

14

Cys → Arg

1

 

94

TTC → GTC

32

Phe → Val

1

 

123

TAC → TAG

41

Tyr → Stop

1

 

146

GAC → GCC

49

Asp → Gly

1

 

146

GAC → GCC

49

Asp → Ala

2

 

151

CAC → TAC

51

His → Tyr

1

 

151

CAC → CGC

51

His → Arg

1

 

152

CAC → CCC

51

His → Pro

1

 

170

CAC → CGC

57

His → Arg

1

 

185

CCG → CTG

62

Pro → Leu

5

 

206

CCG → CTG

69

Pro → Leu

1

 

213

CAT → CAG

71

His → Gln

1

 

226

ACT → CCT

76

Thr → Pro

3

 

232

GGC → AGC

78

Gly → Asp

1

 

245

CAT → CGT

82

His → Arg

1

 

286

AAG → CAG

96

Lys → Gln

1

 

307

TAC → CAC

103

Tyr → His

1

 

309

TAC → TAG

103

Tyr → Stop

1

 

319

GAA → AAA

107

Glu → Lys

1

 

395

GGT → GAT

132

Gly → Asp

9

 

425

ACG → ATG

142

Thr → Met

1

 

437

GCG → GTG

146

Ala → Val

1

 

464

GTG → GGG

155

Val → Gly

1

 

488

GTG → GCG

163

Val → Ala

1

 

515

CTG → CCG

172

Leu → Pro

2

 

52

insertion of GC

 

1

 

130

insertion of C

 

1

 

136

deletion of G

 

2

 

139

insertion of CA

 

1

 

232

insertion of C

 

1

 

243

insertion of T

 

1

 

288

insertion of A

 

1

 

341

deletion of ACGCC

 

1

 

342

deletion of GCCAC

 

2

 

376

deletion of GATGAGGTC

 

1

 

392

insertion of G

 

1

 

392

insertion of GG

 

1

 

393

insertion of GGT

 

1

 

408

insertion of CA

 

1

 

408

insertion of A

 

2

Total

73