|
Variable
|
Enrollees (%)
|
Treatment changes (%)
|
Follow-up/months
|
Rates/ 1000
|
cHazard Ratio*
|
95% CI
|
p-value∞
|
aHazard Ratio#
|
95% CI
|
p-value
|
|---|
|
YEAR
|
N = 3933
|
N = 960
| | | | | | | | |
|
2008
|
836 (21.3)
|
234 (24.4)
|
30,937.9
|
7.56
|
–
|
–
|
–
|
–
|
–
|
–
|
|
2009
|
810 (20.6)
|
240 (25.0)
|
21,883.7
|
10.97
|
1.46
|
1.21 to 1.75
|
<0.0001
|
1.54
|
1.27 to 1.88
|
<0.0001
|
|
2010
|
804 (20.4)
|
280 (29.2)
|
15,640.9
|
17.90
|
2.75
|
2.27 to 3.33
|
<0.0001
|
4.15
|
3.34 to 5.14
|
<0.0001
|
|
2011
|
753 (19.1)
|
171 (17.8)
|
9137.9
|
18.73
|
2.99
|
2.39 to 3.73
|
<0.0001
|
11.55
|
8.70 to 15.35
|
<0.0001
|
|
2012
|
730 (18.6)
|
35 (3.6)
|
3736.3
|
9.37
|
1.33
|
0.91 to 1.94
|
0.139
|
1.43
|
0.89 to 2.33
|
0.153
|
|
HAART TYPE
|
|
AZT/3TC/EFV
|
1468 (37.3)
|
117 (12.2)
|
33,335.5
|
3.51
|
–
|
–
|
–
|
–
|
–
|
–
|
|
AZT/3TC/NVP
|
898 (22.8)
|
90 (9.4)
|
23,238.4
|
3.87
|
1.10
|
0.83 to 1.44
|
0.510
|
1.14
|
0.85 to 1.53
|
0.381
|
|
d4T/3TC/EFV
|
718 (18.3)
|
461 (48.0)
|
12,751.1
|
36.15
|
10.80
|
8.80 to 13.35
|
<0.0001
|
12.05
|
9.58 to 15.16
|
<0.0001
|
|
d4T/3TC/NVP
|
399 (10.1)
|
270 (28.1)
|
7705.4
|
35.04
|
10.42
|
8.38 to 12.96
|
<0.0001
|
12.03
|
9.27 to 15.61
|
<0.0001
|
|
TDF/3TC/EFV
|
314 (8.0)
|
5 (0.5)
|
2528.6
|
1.98
|
0.59
|
0.24 to 1.45
|
0.252
|
0.22
|
0.09 to 0.56
|
0.0013
|
|
TDF/3TC/NVP
|
71 (1.8)
|
3 (0.3)
|
637.5
|
4.71
|
1.43
|
0.45 to 4.50
|
0.542
|
0.58
|
0.18 to 1.85
|
0.358
|
|
OTHERS
|
65 (1.7)
|
14 (1.5)
|
1130.3
|
12.39
|
3.69
|
2.19 to 6.42
|
<0.0001
|
2.99
|
1.71 to 5.23
|
0.0001
|
|
GENDER
|
|
Male
|
1373 (34.9)
|
282 (29.4)
|
28,625.7
|
9.85
|
–
|
–
|
–
|
–
|
–
|
–
|
|
Female
|
2560 (65.1)
|
678 (70.6)
|
52,701.0
|
12.87
|
1.31
|
1.14 to 1.50
|
0.0002
|
1.19
|
1.01 to 1.39
|
0.031
|
|
AGE GROUP
|
|
< 25
|
199 (5.1)
|
44 (4.6)
|
3573.7
|
12.31
|
–
|
–
|
–
|
–
|
–
|
–
|
|
25–34
|
1112 (28.3)
|
277 (28.8)
|
24,080.0
|
11.50
|
0.95
|
0.69 to 1.31
|
0.755
|
1.01
|
0.73 to 1.40
|
0.939
|
|
35–44
|
1251 (31.8)
|
307 (32.0)
|
25,904.0
|
11.85
|
0.97
|
0.71 to 1.33
|
0.864
|
1.03
|
0.75 to 1.42
|
0.871
|
|
45–54
|
709 (18.0)
|
169 (17.6)
|
14,081.4
|
12.00
|
0.99
|
0.71 to 1.37
|
0.945
|
1.09
|
0.78 to 1.54
|
0.605
|
|
55–64
|
192 (4.8)
|
44 (4.6)
|
3633.0
|
12.11
|
0.99
|
0.65 to 1.51
|
0.968
|
0.93
|
0.60 to 1.42
|
0.721
|
|
≥ 65
|
470 (12.0)
|
119 (12.4)
|
10,054.6
|
11.84
|
0.98
|
0.69 to 1.38
|
0.903
|
0.94
|
0.66 to 1.33
|
0.706
|
|
WHO Stage
|
|
I
|
402 (10.2)
|
37 (3.9)
|
5840.4
|
6.34
|
–
|
–
|
–
|
–
|
–
|
–
|
|
II
|
662 (16.8)
|
68 (7.1)
|
14,568.5
|
4.67
|
0.76
|
0.51 to 1.14
|
0.189
|
0.87
|
0.71 to 1.36
|
0.294
|
|
II
|
1042 (26.5)
|
187 (19.4)
|
15,465.5
|
12.09
|
1.93
|
1.36 to 2.74
|
0.0003
|
2.33
|
1.44 to 3.02
|
0.007
|
|
IV
|
491 (12.5)
|
115 (12.0)
|
7901.6
|
14.55
|
2.31
|
1.60 to 3.35
|
<0.0001
|
2.73
|
1.49 to 4.02
|
<0.0001
|
|
Missing
|
1336 (34.0)
|
553 (57.6)
|
37,550.7
|
14.73
|
2.38
|
1.71 to 3.33
|
<0.0001
|
2.83
|
1.82 to 3.88
|
<0.0001
|
- *crude hazard ratios; #adjusted hazard ratios for all other variables
