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Table 6 Predictors of unsuccessful interim treatment outcomes: simple logistic regression analysis

From: Predictors of unsuccessful interim treatment outcomes of multidrug resistant tuberculosis patients

Independent Variable* Interim Treatment outcomes B S.E p-value (OR) 95% CI
Unsuccessful (n = 32) Successful (n = 48)
Age 25–34 (years)
 No 21 42     1
 Yes 11 6 1.299 0.574 .024 3.667 (1.191, 11.285)
Weight†‡ −0.027 0.020 .187 0.974 (0.936, 1.013)
Hb level
 Normal 6 17     1
 Below normal 26 31 0.866 0.544 .112 2.376 (0.818, 6.905)
Creatinine level
 Normal 19 42     1
 Above normal 11 6 1.399 0.578 .015 4.053 (1.306, 12.580)
Previous TB episodes 0.456 0.315 .148 1.577 (0.850, 2.927)
Months of sickness with TB
  < 12 21 24     1
  ≥ 12 11 24 −0.647 0.471 .170 0.524 (0.208, 1.319)
Previous TB treatment outcome failed
 No 30 40     1
 Yes 2 8 −1.099 0.827 .184 0.333 (0.066, 1.685)
History of streptomycin use
 No 15 37     1
 Yes 17 11 1.338 0.493 .007 3.812 (1.449, 10.026)
Number of first line drugs with resistance
  < 4 11 8     1
  ≥ 4 14 22 −0.770 0.577 .182 0.463 (0.149, 1.434)
Ofloxacin resistance
 Present 14 35     1
 Absent 18 13 1.242 0.482 .010 3.462 (1.345, 8.906)
Sputum grading‡¶
 Low 17 35     1
 High 10 9 0.827 0.546 .130 2.288 (0.784, 6.675)
Positive culture after two months of treatment
 No 11 40     1
 Yes 21 8 2.256 0.537 < 0.01 9.545 (3.331, 27.354)
  1. p-value less than 0.05 in bold
  2. * Variables tested but not included in this Table because the p-value was greater than .20: sex, residence, being married, smoking status, concurrent comorbidities, family history of TB, number of resistant drugs, resistant to any second line anti-TB drug, base line sputum results, baseline levels of hemoglobin, serum glutamate pyruvate transaminase, sputum positive after two months of treatment, adverse events observed during six months of treatment
  3. Continuous variable,
  4. Baseline values
  5. Variables with greater than 10% missing values
  6. AFB = Acid Fast Bacilli; Hb = Hemoglobin; HPF; High Power Field; MDR-TB = Multidrug-Resistant TB; TB =Tuberculosis