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Table 2 Risk factors for overall 90-day mortality in allo-HSCT recipients with S. maltophilia bacteremia

From: Predictive implications of albumin and C-reactive protein for progression to pneumonia and poor prognosis in Stenotrophomonas maltophilia bacteremia following allogeneic hematopoietic stem cell transplantation

 

Univariate analysis

Multivariate analysis

 

Probability of survival

p-value

Hazard ratio

95% CI

p-value

Age (years)

≥60

0.63 (0.45–0.77)

0.13

   

<60

0.42 (0.15–0.67)

    

Sex

Male

0.60 (0.41–0.75)

0.67

   

Female

0.53 (0.28–0.73)

    

CRP (mg/dl)

≥10

0.29 (0.09–0.52)

<0.01

3.28

1.00–10.72

0.05

<10

0.70 (0.51–0.82)

    

Albumin (g/dl)

<3.0

0.13 (0.02–0.33)

<0.01

10.86

3.27–36.12

<0.01

≥3.0

0.79 (0.59–0.90)

    

Creatinine (mg/dl)

≥1.0

0.25 (0.06–0.51)

<0.01

   

<1.0

0.69 (0.51–0.81)

    

Neutropenia (≤500 /μl)

Yes

0.55 (0.36–0.70)

0.52

   

No

0.63 (0.35–0.81)

    

Profound neutropenia (≤100 /μl)

Yes

0.48 (0.26–0.67)

0.1

   

No

0.65 (0.44–0.80)

    

Prolonged neutropenia (≥7 days)

Yes

0.79 (0.47–0.93)

0.08

   

No

0.49 (0.31–0.64)

    

Onset of bacteremia

During conditioning

1.00 (1.00–1.00)

0.73

   

Before engraftment

0.60 (0.32–0.80)

    

After engraftment

0.55 (0.36–0.70)

    

Existence of acute GVHD

Yes

0.47 (0.21–0.69)

0.44

   

No

0.63 (0.44–0.77)

    

Diarrhea

Yes

0.62 (0.40–0.77)

0.64

   

No

0.52 (0.30–0.71)

    

Mucositis

Yes

0.60 (0.36–0.78)

0.89

   

No

0.56 (0.35–0.72)

    

Primary disease risk

High

0.40 (0.21–0.58)

<0.01

   

Standard

0.77 (0.54–0.89)

    

Polymicrobial bacteremia

Yes

0.58 (0.33–0.76)

0.88

   

No

0.57 (0.37–0.73)

    

Severe sepsis or septic shock

Yes

0.30 (0.12–0.50)

<0.01

   

No

0.78 (0.57–0.89)

    

Initial source of infection

Sources unknown

0.58 (0.37–0.74)

<0.01

   

Cellulitis

1.00 (1.00–1.00)

    

CLABSI

0.69 (0.37–0.87)

    

Pneumonia

0.00 (NA)

    

Time to appropriate therapy (days)

≥4

0.76 (0.54–0.88)

0.05

   

≤3

0.47 (0.23–0.68)

    

Removal of CVC

Yes

0.92 (0.57–0.99)

<0.01

   

No

0.44 (0.27–0.60)

    

Past history of carbapenem

Yes

0.46 (0.26–0.64)

0.05

   

No

0.70 (0.47–0.84)

    

Source of transplantation

BM

0.62 (0.43–0.76)

0.17

   

PB

0.57 (0.17–0.84)

    

CB

0.33 (0.05–0.68)

    

Donor type

Related

0.80 (0.41–0.95)

0.1

   

Unrelated

0.51 (0.34–0.66)

    

HLA-matching

Match

0.64 (0.40–0.79)

0.38

   

Mismatch

0.52 (0.31–0.69)

    

Conditioning

Myeloablative

0.73 (0.54–0.85)

<0.01

   

Reduced-intensity

0.21 (0.05–0.45)

    

Study period

2005–2009

0.57 (0.28–0.78)

0.95

   

2010–2014

0.58 (0.39–0.72)

    
  1. Abbreviations: Allo-HSCT allogeneic hematopoietic stem cell transplantation, S. maltophilia Stenotrophomonas maltophilia, CI confedence interval, CRP c-reactive protein, GVHD graft-versus-host disease, CLABSI central-line associated blood stream infection, CVC central venous catheter, NA not available, BM bone marrow, PB peripheral blood, CB cord blood, HLA human leukocyte antigen
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BMC Infectious Diseases

ISSN: 1471-2334

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