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Table 2 Risk factors for overall 90-day mortality in allo-HSCT recipients with S. maltophilia bacteremia

From: Predictive implications of albumin and C-reactive protein for progression to pneumonia and poor prognosis in Stenotrophomonas maltophilia bacteremia following allogeneic hematopoietic stem cell transplantation

  Univariate analysis Multivariate analysis
  Probability of survival p-value Hazard ratio 95% CI p-value
Age (years) ≥60 0.63 (0.45–0.77) 0.13    
<60 0.42 (0.15–0.67)     
Sex Male 0.60 (0.41–0.75) 0.67    
Female 0.53 (0.28–0.73)     
CRP (mg/dl) ≥10 0.29 (0.09–0.52) <0.01 3.28 1.00–10.72 0.05
<10 0.70 (0.51–0.82)     
Albumin (g/dl) <3.0 0.13 (0.02–0.33) <0.01 10.86 3.27–36.12 <0.01
≥3.0 0.79 (0.59–0.90)     
Creatinine (mg/dl) ≥1.0 0.25 (0.06–0.51) <0.01    
<1.0 0.69 (0.51–0.81)     
Neutropenia (≤500 /μl) Yes 0.55 (0.36–0.70) 0.52    
No 0.63 (0.35–0.81)     
Profound neutropenia (≤100 /μl) Yes 0.48 (0.26–0.67) 0.1    
No 0.65 (0.44–0.80)     
Prolonged neutropenia (≥7 days) Yes 0.79 (0.47–0.93) 0.08    
No 0.49 (0.31–0.64)     
Onset of bacteremia During conditioning 1.00 (1.00–1.00) 0.73    
Before engraftment 0.60 (0.32–0.80)     
After engraftment 0.55 (0.36–0.70)     
Existence of acute GVHD Yes 0.47 (0.21–0.69) 0.44    
No 0.63 (0.44–0.77)     
Diarrhea Yes 0.62 (0.40–0.77) 0.64    
No 0.52 (0.30–0.71)     
Mucositis Yes 0.60 (0.36–0.78) 0.89    
No 0.56 (0.35–0.72)     
Primary disease risk High 0.40 (0.21–0.58) <0.01    
Standard 0.77 (0.54–0.89)     
Polymicrobial bacteremia Yes 0.58 (0.33–0.76) 0.88    
No 0.57 (0.37–0.73)     
Severe sepsis or septic shock Yes 0.30 (0.12–0.50) <0.01    
No 0.78 (0.57–0.89)     
Initial source of infection Sources unknown 0.58 (0.37–0.74) <0.01    
Cellulitis 1.00 (1.00–1.00)     
CLABSI 0.69 (0.37–0.87)     
Pneumonia 0.00 (NA)     
Time to appropriate therapy (days) ≥4 0.76 (0.54–0.88) 0.05    
≤3 0.47 (0.23–0.68)     
Removal of CVC Yes 0.92 (0.57–0.99) <0.01    
No 0.44 (0.27–0.60)     
Past history of carbapenem Yes 0.46 (0.26–0.64) 0.05    
No 0.70 (0.47–0.84)     
Source of transplantation BM 0.62 (0.43–0.76) 0.17    
PB 0.57 (0.17–0.84)     
CB 0.33 (0.05–0.68)     
Donor type Related 0.80 (0.41–0.95) 0.1    
Unrelated 0.51 (0.34–0.66)     
HLA-matching Match 0.64 (0.40–0.79) 0.38    
Mismatch 0.52 (0.31–0.69)     
Conditioning Myeloablative 0.73 (0.54–0.85) <0.01    
Reduced-intensity 0.21 (0.05–0.45)     
Study period 2005–2009 0.57 (0.28–0.78) 0.95    
2010–2014 0.58 (0.39–0.72)     
  1. Abbreviations: Allo-HSCT allogeneic hematopoietic stem cell transplantation, S. maltophilia Stenotrophomonas maltophilia, CI confedence interval, CRP c-reactive protein, GVHD graft-versus-host disease, CLABSI central-line associated blood stream infection, CVC central venous catheter, NA not available, BM bone marrow, PB peripheral blood, CB cord blood, HLA human leukocyte antigen