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Table 1 S.agalactiae Sputum Isolates and Exacerbation Status in Adult Cystic Fibrosis Patients

From: Group B streptococcus (GBS) is an important pathogen in human disease- but what about in cystic fibrosis?

Isolate Patient Date of Isolation CFUa GBS Most Abundant Reduced FEV1 b PExc * ABx Required Co-Infectionsd
1 1 1990 104 N N Y Y HI
2 2 2005 104 N N N PA
3 3 1994 106 N Y Y* Y MSSA, SM
4 4 2013 106 Equal N N PA
5 5 2012 106 N N Y Y PA
6 5 −2012 104 N Y N PA
7 5 −2012 105 N N N PA
8 5 2012 106 Equal N N PA
9 5 2013 N/A Equal Y N PA
10 5 2013 105 N N N N PA
11 5 2013 106 N N Y Y PA
12 5 2013 107 Y Y Y* Y PA
13 6 1992 105 N N N PA, MSSA
14 7 1986 104 N N/A Y* Y PA
15 7 1986 N/A Y N N
16 7 1986 N/A Y N N
17 7 1987 106 N N N HI
18 7 1987 105 N Y N O
19 7 1987 105 N/A N N N/A
20 7 1987 104 N N N
21 8 2011 105 Equal N N MSSA
22 9 2013 106 Y N N
23 10 2013 106 Equal N N MSSA
24 11 1990 105 N N Y Y PA
25 11 1991 106 Y N N PA
26 11 1992 106 Equal N N PA
27 11 1992 104 Equal N Y Y PA
28 11 1993 108 Y N Y Y PA
29 11 1993 107 N N N PA, O
30 11 1993 107 Equal N N PA, O
  1. aCFU = colony forming units
  2. bReduced FEV1 = reduction in reduction in FEV1 by >10% and/or >200cm3 at time of isolate compared to baseline FEV1
  3. cPEx = pulmonary exacerbation as defined by Fuch’s Criteria and/or need for antibiotics
  4. *Severe PEx = pulmonary exacerbation requiring intravenous antibiotics and/or hospitalization
  5. dHI: Haemophilus influenza, PA: Pseudomonas aeruginosa, MSSA: Methicillin sensitive S. aureus, SM = Stenotrophomonas maltophilia, S.marcecens = Serratia marcecens, Bc: Burkholderia cenocepacia, CA: Candida albicans, O: other N/A = Not available N = No Y = Yes