Group B streptococcus (GBS) is an important pathogen in human disease- but what about in cystic fibrosis?

BMC Infectious Diseases

Table 1 S.agalactiae Sputum Isolates and Exacerbation Status in Adult Cystic Fibrosis Patients

Isolate	Patient	Date of Isolation	CFU^a	GBS Most Abundant	Reduced FEV₁ ^b	PEx^c *	ABx Required	Co-Infections^d
1	1	1990	10⁴	N	N	Y	Y	HI
2	2	2005	10⁴	N	N	N	–	PA
3	3	1994	10⁶	N	Y	Y*	Y	MSSA, SM
4	4	2013	10⁶	Equal	N	N	–	PA
5	5	2012	10⁶	N	N	Y	Y	PA
6	5	−2012	10⁴	N	Y	N	–	PA
7	5	−2012	10⁵	N	N	N	–	PA
8	5	2012	10⁶	Equal	N	N	–	PA
9	5	2013	N/A	Equal	Y	N	–	PA
10	5	2013	10⁵	N	N	N	N	PA
11	5	2013	10⁶	N	N	Y	Y	PA
12	5	2013	10⁷	Y	Y	Y*	Y	PA
13	6	1992	10⁵	N	N	N	–	PA, MSSA
14	7	1986	10⁴	N	N/A	Y*	Y	PA
15	7	1986	N/A	Y	N	N	–	–
16	7	1986	N/A	Y	N	N	–	–
17	7	1987	10⁶	N	N	N	–	HI
18	7	1987	10⁵	N	Y	N	–	O
19	7	1987	10⁵	N/A	N	N	–	N/A
20	7	1987	10⁴	N	N	N	–	–
21	8	2011	10⁵	Equal	N	N	–	MSSA
22	9	2013	10⁶	Y	N	N	–	–
23	10	2013	10⁶	Equal	N	N	–	MSSA
24	11	1990	10⁵	N	N	Y	Y	PA
25	11	1991	10⁶	Y	N	N	–	PA
26	11	1992	10⁶	Equal	N	N	–	PA
27	11	1992	10⁴	Equal	N	Y	Y	PA
28	11	1993	10⁸	Y	N	Y	Y	PA
29	11	1993	10⁷	N	N	N	–	PA, O
30	11	1993	10⁷	Equal	N	N	–	PA, O

^aCFU = colony forming units
^bReduced FEV1 = reduction in reduction in FEV₁ by >10% and/or >200cm³ at time of isolate compared to baseline FEV₁
^cPEx = pulmonary exacerbation as defined by Fuch’s Criteria and/or need for antibiotics
^*Severe PEx = pulmonary exacerbation requiring intravenous antibiotics and/or hospitalization
^dHI: Haemophilus influenza, PA: Pseudomonas aeruginosa, MSSA: Methicillin sensitive S. aureus, SM = Stenotrophomonas maltophilia, S.marcecens = Serratia marcecens, Bc: Burkholderia cenocepacia, CA: Candida albicans, O: other N/A = Not available N = No Y = Yes

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