Table 3 Predictive accuracy of ACI and other index for diagnosing significant fibrosis in total patients
Index | Patients | AUC (95% CI) | Cut-off | Sensiti -vity (%) | Speci-ficit (%) | PPV (%) | NPV (%) | LR |
|---|---|---|---|---|---|---|---|---|
ACI | ALT <2 × ULN (n = 460) | 0.813 (95% CI: 0.772, 0.854) | ≥0.2 | 88.0 | 50.9 | 51.3 | 90.8 | 1.6 |
≥0.3 | 76.1 | 74.4 | 64.0 | 84.0 | 2.97 | |||
≥0.5 | 50.9 | 90.0 | 66.7 | 74.9 | 4.80 | |||
Normal ALT (n = 196) | 0.824 (95% CI: 0.763, 0.884) | ≥0.2 | 81.8 | 63.7 | 54.0 | 87.5 | 2.25 | |
≥0.3 | 65.2 | 86.3 | 66.1 | 84.0 | 4.75 | |||
≥0.5 | 40.0 | 94.4 | 75.7 | 75.9 | 6.98 | |||
APRI | ALT <2 × ULN (n = 460) | 0.742 (95%CI: 0.695, 0.789) | ≥0.5 | 70.0 | 63.6 | 53.9 | 78.8 | 2.07 |
≥1.0 | 26.4 | 94.4 | 73.8 | 68.9 | 4.71 | |||
Normal ALT (n = 196) | 0.780 (95% CI: 0.710, 0.849) | ≥0.5 | 55.2 | 85.8 | 58.9 | 78.3 | 3.90 | |
≥1.0 | 16.4 | 98.4 | 84.6 | 69.1 | 10.43 | |||
FIB-4 | ALT <2 ULN (n = 460) | 0.741 (95% CI: 0.693, 0.788) | ≥1.0 | 89.6 | 34.2 | 43.9 | 66.4 | 1.42 |
≥1.5 | 17.7 | 96.4 | 75.6 | 67.1 | 4.97 | |||
Normal ALT (n = 196) | 0.763 (95% CI: 0.689, 0.830) | ≥1.0 | 90.8 | 31.8 | 40.4 | 86.7 | 1.33 | |
≥1.5 | 21.5 | 96.8 | 77.8 | 70.5 | 6.78 | |||
Forns’ index | ALT <2 × ULN (n = 460) | 0.766 (95% CI: 0.717, 0.816) | ≥6.0 | 90.1 | 37.5 | 44.9 | 86.8 | 1.44 |
≥8.0 | 54.6 | 83.5 | 64.7 | 75.8 | 3.3 | |||
Normal ALT (n = 196) | 0.762 (95% CI: 0.689, 0.847) | ≥6.0 | 86.54 | 40.38 | 41.3 | 85.1 | 1.43 | |
≥8.0 | 50.0 | 87.5 | 67.5 | 78.4 | 4.00 | |||
Hui Model | ALT <2 × ULN (n = 460) | 0.736 (95% CI: 0.686, 0.787) | ≥0.15 | 60.1 | 74.4 | 58.1 | 76.5 | 2.55 |
≥0.3 | 38.5 | 90.9 | 71.3 | 71.7 | 4.25 | |||
Normal ALT (n = 196) | 0.745 (95% CI: 0.664, 0.825) | ≥0.15 | 51.8 | 81.8 | 58.8 | 77.4 | 2.85 | |
≥0.3 | 33.9 | 91.8 | 66.7 | 72.7 | 4.15 | |||
≥0.3 | 33.9 | 91.8 | 66.7 | 72.7 | 4.15 |