Correlates of isoniazid preventive therapy failure in child household contacts with infectious tuberculosis in high burden settings in Nairobi, Kenya – a cohort study

Table 4 Variables in the equation on logistic regression

	B	S.E.	Wald	df	Sig.	Exp (B)	95% C.I. for EXP (B)
							Lower	Upper
Index cases per household^a							0.013	1.199
Crowding index >5 at night^b	0.017	0.373	0.002	1	0.963	0.983	0.473	2.044
Index case HIV status	−1.299	1.517	0.734	1	0.392	0.273	0.014	5.330
Malnutrition/ weight faltering^c	2.649	1.352	3.836	1	0.050^e	14.137	0.998	200.237
Contact’s HIV DNA PCR test	2.504	1.705	2.157	1	0.142	12.225	0.433	345.312
Baseline TST reaction	2.275	1.312	3.006	1	0.083	9.731	0.743	127.444
Gender of index case	−18.892	2295.193	0.000	1	0.993	0.000	0.000	.
TB suggestive symptoms^d at enrollment	−14.923	4064.238	0.000	1	0.997	0.000	0.000	.
Side effects reported in child	−2.922	1.930	2.292	1	0.130	0.054	0.000	–
Constant	32.920	4667.541	0.000	1	0.994	1.981	–	–

^a Number of smear positive index cases in the household in the preceding 3 months, ^b crowding index at night was obtained by number of all persons sleeping in the house divided by the number of rooms in the house, ^c malnutrition was present in those with any weight faltering on their growth charts and those who had under-nutrition <80%, ^d TB suggestive symptoms included those with cough ≥2 weeks, fever ≥2 weeks, weight loss, fatigue, reduced play, or any swellings. ^e statistically significant factors. BCG Bacille Calmette-Guerin vaccine, HIV Human Immune Deficiency virus, DNA Deoxyribonucleic acid, PCR polymerase chain reaction, TB tuberculosis, TST tuberculin skin test

ISSN: 1471-2334