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Table 1 Index case and household factors influencing IPT outcomes

From: Correlates of isoniazid preventive therapy failure in child household contacts with infectious tuberculosis in high burden settings in Nairobi, Kenya – a cohort study

Characteristics   TB disease No TB disease Fisher’s exact test (P value) ORa
95% CI
Age (years) ≤ 30 6 279 0.19
>30 0 83  
Gender Female 6 177 0.02c
Male 0 185  
Residence Informal settling 5 261 1.00 1.93
Peri-urban 1 101 0.55 –16.77
Marital status Married 5 276 1.00 1.55
Single 1 86 0.18–13.52
Level of education ≤ Secondary 6 308 0.60
Tertiary 0 54  
Occupation Unemployed 2 256 0.068 4.83
employed 4 106 0.87–26.77
Relationship to child Parent 5 270 1.00 1.70
Othersd 1 92 0.19–14.77
Crowding index at nighte >5 4 74 0.02c 7.78
≤4 2 288 1.39–43.31
Number of index cases per household 1 2 326 0.01c 0.54
>1 4 35 0.01–0.30
Shared bedroom with contact Always 5 293 1.00 0.85
Sometimes 1 69 0.02–7.39
Separate Cooking room Yes 1 79 1.00 1.40
No 5 283 0.16 –12. 12
Duration of symptoms prior to TB diagnosisb ≤ 4 weeks 0 107 0.19
>4 weeks 6 255  
HIV status Positive 4 74 0.02c 7.78
Negative 2 288 0.02–43. 32
Knowledge of TB causation Bacteria 5 256 0.68 2.07
Other 1 106 0.24–17.93
Knowledge of TB risk factors in children Good/Average 3 116 0.64 2.07
Poor 3 246 0.24 –17. 93
TB/HIV relationship knowledgef Good/Average 3 200 0.04c 0.95
Poor 3 304 0.11–8.32
TB myths and perceptions Present 1 304 0.63 0.95
None 5 58 0.11–8.32
  1. aOR is presented in the top cell and CI in lower cell. b Time from onset of symptoms was calculated from the date the participant reported to start coughing until the date of treatment registered, c statistically significant factors. d Sibling, relative, or friend. e crowding index at night was obtained by number of all persons sleeping in the house divided by the number of rooms in the house, f Knowledge that HIV predisposes to tuberculosis. CI confidence interval, OR odds ratio, TB tuberculosis, HIV Human Immune Deficiency virus