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Table 1 Index case and household factors influencing IPT outcomes

From: Correlates of isoniazid preventive therapy failure in child household contacts with infectious tuberculosis in high burden settings in Nairobi, Kenya – a cohort study

Characteristics

 

TB disease

No TB disease

Fisher’s exact test (P value)

ORa

95% CI

Age (years)

≤ 30

6

279

0.19

>30

0

83

 

Gender

Female

6

177

0.02c

Male

0

185

 

Residence

Informal settling

5

261

1.00

1.93

Peri-urban

1

101

0.55 –16.77

Marital status

Married

5

276

1.00

1.55

Single

1

86

0.18–13.52

Level of education

≤ Secondary

6

308

0.60

Tertiary

0

54

 

Occupation

Unemployed

2

256

0.068

4.83

employed

4

106

0.87–26.77

Relationship to child

Parent

5

270

1.00

1.70

Othersd

1

92

0.19–14.77

Crowding index at nighte

>5

4

74

0.02c

7.78

≤4

2

288

1.39–43.31

Number of index cases per household

1

2

326

0.01c

0.54

>1

4

35

0.01–0.30

Shared bedroom with contact

Always

5

293

1.00

0.85

Sometimes

1

69

0.02–7.39

Separate Cooking room

Yes

1

79

1.00

1.40

No

5

283

0.16 –12. 12

Duration of symptoms prior to TB diagnosisb

≤ 4 weeks

0

107

0.19

>4 weeks

6

255

 

HIV status

Positive

4

74

0.02c

7.78

Negative

2

288

0.02–43. 32

Knowledge of TB causation

Bacteria

5

256

0.68

2.07

Other

1

106

0.24–17.93

Knowledge of TB risk factors in children

Good/Average

3

116

0.64

2.07

Poor

3

246

0.24 –17. 93

TB/HIV relationship knowledgef

Good/Average

3

200

0.04c

0.95

Poor

3

304

0.11–8.32

TB myths and perceptions

Present

1

304

0.63

0.95

None

5

58

0.11–8.32

  1. aOR is presented in the top cell and CI in lower cell. b Time from onset of symptoms was calculated from the date the participant reported to start coughing until the date of treatment registered, c statistically significant factors. d Sibling, relative, or friend. e crowding index at night was obtained by number of all persons sleeping in the house divided by the number of rooms in the house, f Knowledge that HIV predisposes to tuberculosis. CI confidence interval, OR odds ratio, TB tuberculosis, HIV Human Immune Deficiency virus