Skip to main content

Table 3 Univariate and multivariate analyses of the factors associated with IFN-γ production in response 38KDa/CFP-10 antigen

From: Risk factors for increased immune reconstitution in response to Mycobacterium tuberculosis antigens in tuberculosis HIV-infected, antiretroviral-naïve patients

Factor

Univariable

 

Multivariablea

 
 

(IC95%)

P-value

(IC95%)

P-value

Baseline CD4

 ≥ 200 cells/mm3

1

   

 < 200 cells/mm3

1.189 (0.341; 4.143)

0.786

  

Gender

 Male

1

   

 Female

0.5 (0.131; 1.9)

0.309

  

Age (Year)

 38–44

1

   

 32–18

0.928 (0.225; 3.828)

0.917

  

 37–32

1.594 (0.371; 6.855)

0.531

  

Site of tuberculosis

 Pulmonary

1

 

1

 

 Disseminated

1.308 (0.345; 4.954)

0.693

1.632 (0.469; 5.681)

0.441

 Extrapulmonary

3.84 (0.895; 16.474)

0.070

3.054 (0.889; 10.494)

0.076

Ethnicity

 White

1

   

 Black

2.128 (0.373; 12.15)

0.396

  

 Mulattoes

1.29 (0.36; 4.619)

0.696

  

Efavirenz dose

 600 mg

1

 

1

 

 800 mg

2.29 (0.658; 7.971)

0.193

2.765 (0.862; 8.865)

0.087

HIV-1 viral load

 Detectable

1

 

1

 

 Undetectable

2.078 (1.19; 3.627)

0.010

2.217 (1.258; 3.906)

0.006

 Follow-up CD4 cells/mm3

    

 < 200 cells/mm3

0.999 (0.994; 1.003)

0.559

  

 ≥ 200cells/mm3

1.002 (1; 1.004)

0.015

1.002 (1; 1.003)

0.013

Follow-up %HLA-DR+/CD3+ T cells

1.007 (0.993; 1.022)

0.340

  

Follow-up % CD8+/38+ T cells

1.008 (0.992; 1.025)

0.327

1.017 (0.999; 1.035)

0.061

Follow-up IFN-γ plasmatic

0.995 (0.951; 1.04)

0.817

  
  1. aThe predictors in 38 K Da/CFP-10 antigen final model are as follow: Follow-up CD4 cells/mm3 (≥ 200cells/mm3), Site of tuberculosis, Efavirenz dose, HIV-1 viral load and Follow-up % CD8+/38+ T cells