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Table 3 Univariate and multivariate analyses of the factors associated with IFN-γ production in response 38KDa/CFP-10 antigen

From: Risk factors for increased immune reconstitution in response to Mycobacterium tuberculosis antigens in tuberculosis HIV-infected, antiretroviral-naïve patients

Factor Univariable   Multivariablea  
  (IC95%) P-value (IC95%) P-value
Baseline CD4
 ≥ 200 cells/mm3 1    
 < 200 cells/mm3 1.189 (0.341; 4.143) 0.786   
Gender
 Male 1    
 Female 0.5 (0.131; 1.9) 0.309   
Age (Year)
 38–44 1    
 32–18 0.928 (0.225; 3.828) 0.917   
 37–32 1.594 (0.371; 6.855) 0.531   
Site of tuberculosis
 Pulmonary 1   1  
 Disseminated 1.308 (0.345; 4.954) 0.693 1.632 (0.469; 5.681) 0.441
 Extrapulmonary 3.84 (0.895; 16.474) 0.070 3.054 (0.889; 10.494) 0.076
Ethnicity
 White 1    
 Black 2.128 (0.373; 12.15) 0.396   
 Mulattoes 1.29 (0.36; 4.619) 0.696   
Efavirenz dose
 600 mg 1   1  
 800 mg 2.29 (0.658; 7.971) 0.193 2.765 (0.862; 8.865) 0.087
HIV-1 viral load
 Detectable 1   1  
 Undetectable 2.078 (1.19; 3.627) 0.010 2.217 (1.258; 3.906) 0.006
 Follow-up CD4 cells/mm3     
 < 200 cells/mm3 0.999 (0.994; 1.003) 0.559   
 ≥ 200cells/mm3 1.002 (1; 1.004) 0.015 1.002 (1; 1.003) 0.013
Follow-up %HLA-DR+/CD3+ T cells 1.007 (0.993; 1.022) 0.340   
Follow-up % CD8+/38+ T cells 1.008 (0.992; 1.025) 0.327 1.017 (0.999; 1.035) 0.061
Follow-up IFN-γ plasmatic 0.995 (0.951; 1.04) 0.817   
  1. aThe predictors in 38 K Da/CFP-10 antigen final model are as follow: Follow-up CD4 cells/mm3 (≥ 200cells/mm3), Site of tuberculosis, Efavirenz dose, HIV-1 viral load and Follow-up % CD8+/38+ T cells