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Table 2 Univariate and multivariate analyses of the factors associated with IFN-γ production in response to the PPD antigen

From: Risk factors for increased immune reconstitution in response to Mycobacterium tuberculosis antigens in tuberculosis HIV-infected, antiretroviral-naïve patients

Factor

Univariable

 

Multivariablea

 
 

(IC95%)

P-value

(IC95%)

P-value

Baseline CD4

 ≥ 200 cells/mm3

1

 

1

 

 < 200 cells/mm3

1.375 (0.332;5.694)

0.661

5.547 (1.348;22.821)

0.018

Gender

 Male

1

   

 Female

0.242 (0.052; 1.118)

0.069

  

Age (Year)

 38–44

1

 

1

 

 32–18

3.87 (1.336;11.212)

0.013

2.808 (1.13;6.98)

0.026

 37–32

1.256 (0.305;5.169)

0.752

1.061 (0.292; 3.862)

0.928

Site of tuberculosis

 Pulmonary

1

 

1

 

 Disseminated

1.173 (0.285; 4.836)

0.825

1.531 (0.468; 5.01)

0.482

 Extrapulmonary

4.275 (1.122; 16.285)

0.033

6.431 (1.566; 26.408)

0.010

Ethnicity

 White

1

   

 Black

2.544 (0.603; 10.737)

0.204

  

 Mulattoes

1.376 (0.283; 6.705)

0.692

  

Efavirenz dose

 600 mg

1

 

1

 

 800 mg

3.187 (0.901;11.266)

0.072

3.505 (1.04;11.817)

0.043

HIV-1 viral load

 Detectable

1

   

 Undetectable

2.348 (1.228;4.489)

0.010

  

 Follow-up CD4 cells/mm3

    

 ≥200 cells/mm3

1.003 (1.001; 1.005)

0.002

1.006 (1.003; 1.009)

<0.001

 <200 cells/mm3

1.004 (0.996; 1.1014)

0.312

1.011 (1.002; 1.02)

0.016

Follow-up %HLA-DR+/CD3+ T cells

0.994 (0.975; 1.014)

0.559

  

Follow-up % CD8+/38+ T cells

0.998 (0.972; 1.024)

0.851

  

Follow-up IFN-γ plasmatic

0.989 (0.946; 1.033)

0.61

  
  1. aThe predictors in the PPD antigen final model are as follows: Baseline CD4, Age, Site of tuberculosis, Efavirenz dose, Follow-up CD4 ≥ 200 cells/mm3 and Follow-up CD4 < 200 cells/mm3