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Table 3 Analysis of mutation in the BCP, precore/core gene reported to be associated with HCC in 135 HBV isolates from southern Vietnam

From: Molecular characterization of hepatitis B virus in Vietnam

Nucleotide

All isolates

N = 135% (n)

Genotype B

N = 98% (n)

Genotype C

N = 37% (n)

p value

Mutation in BCP region

 C1653T

0.7 (1)

1.1 (1)

0.0 (0)

0.726

 T1753C

11.1 (15)

1.1 (1)

37.8 (14)

0.000

 G1757A

7.4 (10)

0 (0)

27.0 (10)

0.000

 A1762T

25.9 (35)

10.2 (10)

76.6 (25)

0.000

 G1764A

24.4 (33)

8.2 (8)

76.6 (25)

0.000

 A1762T/G1764A

24.4 (33)

8.2 (8)

76.6 (25)

0.000

 C1766G

2.2 (3)

2.0 (2)

2.7 (1)

0.621

 T1768A

1.4 (2)

1.1 (1)

2.7 (1)

0.475

Mutation in PC/Core

 G1896A

22.2 (30)

30.6 (30)

0 (0)

0.000

 G1899A

0.7 (1)

1.1 (1)

0 (0)

0.726

 A2159G

3.7 (5)

3.1 (3)

5.4 (2)

0.419

 A2189C

6.7 (9)

6.1 (6)

8.1 (3)

0.469

 G2203A/T

0.7 (1)

1.0 (1)

0.0 (0)

0.726