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Table 3 Vaccine and non-vaccine serotypes of S. pneumoniae identified in patients with invasive pneumococcal disease cared for in Regional Health Care Network 13, according to the isolation period, 1998 to 2013

From: Distribution of Streptococcus pneumoniae serotypes in the northeast macro-region of São Paulo state/Brazil after the introduction of conjugate vaccine

Serotypes Periods Total
1998–2002 2003–2010 2011–2013
no %* no %* no %* no %
PCV7         
 14 45 20.3 94 19.6 6 6.3 145 18.2
 19F 15 6.8 28 5.8 3 3.2 46 5.8
 6B 7 3.2 27 5.6 4 4.2 38 4.8
 23F 8 3.6 29 6.1 0 0.0 37 4.6
 9V 6 2.7 25 5.2 3 3.2 34 4.3
 18C 13 5.9 15 3.1 5 5.3 33 4.1
 4 8 3.6 13 2.7 3 3.2 24 3.0
 Total PCV7 102 45.9 231 48.2 24 25.3 357 44.8
Included PCV10         
 1 12 5.4 31 6.5 0 0.0 43 5.4
 7 F 7 3.2 12 2.5 2 2.1 21 2.6
 5 14 6.3 1 0.2 2 2.1 17 2.1
 Total PCV10 33 14.9 44 9.2 4 4.2 81 10.2
Included PCV13         
 3 14 6.3 42 8.8 17 17.9 73 9.2
 6A 13 5.9 20 4.2 6 6.3 39 4.9
 19A 13 5.9 18 3.8 2 2.1 33 4.1
 Total PCV13 40 18.0 80 16.7 25 26.3 145 18.2
Non-vaccine         
 12F 1 0.5 18 3.8 9 9.5 28 3.5
 11A 0 0.0 12 2.5 3 3.2 15 1.9
 22F 3 1.4 12 2.5 0 0.0 15 1.9
 8 2 0.9 5 1.0 5 5.3 12 1.5
 9N 1 0.5 6 1.3 3 3.2 10 1.3
 10A 3 1.4 5 1.0 1 1.1 9 1.1
 15C 2 0.9 3 0.6 4 4.2 9 1.1
 17F 3 1.4 5 1.0 0 0.0 8 1.0
 6C 1 0.5 3 0.6 4 4.2 8 1.0
 18A 4 1.8 3 0.6 0 0.0 7 0.9
 18B 2 0.9 5 1.0 0 0.0 7 0.9
 23B 1 0.5 5 1.0 0 0.0 6 0.8
 NT 3 1.4 3 0.6 0 0.0 6 0.8
 NR 0 0.0 2 0.4 0 0.0 2 0.3
 Othera 21 9.5 37 7.7 13 13.7 71 8.9
 Total non- vaccine 47 21.2 124 25.9 42 44.2 215 27.0
 Total 222 100.0 479 100.0 95 100.0 796 100.0
  1. %* refers to the total casos of IPDs in each period, Other aserotypes with less than 6 isolates
  2. NT Non-typable, NR Not carried out (unviable strain)
  3. PCV7 – valent pneumococcal conjugate vaccine
  4. PCV10–10-valent pneumococcal conjugate vaccine
  5. PCV13–13-valent pneumococcal conjugate vaccine