Suitability of saliva for Tuberculosis diagnosis: comparing with serum

BMC Infectious Diseases

Table 6 Median marker levels in saliva between the active PTB group and those with other respiratory infections and area under the curve (AUC) showing diagnostic performance of markers

Marker	Median (pg/ml) PTB	Median (pg/ml) ORD	p-value	AUC	Sensitivity	Specificity	Cut off
IL-2	0.0 (0.0–0.0)	0.0 (0.0–0.0)	0.57	0.53	89.74	15.38	<0.38
IL-5	1.6 (0.6–2.1)	1.6 (0.6–2.1)	0.52	0.54	12.82	97.44	<0.12
IL-6	5.11 (2.4–9.5)	4.8 (2.1–6.4)	0.23	0.58	25.64	89.74	<2.1
G-CSF	0.0 (0.0–40.5)	0.0 (0.0–53.2)	0.64	0.53	17.95	92.31	>86.61
GM-CSF	257.9 (77.9–428.9)	282.2 (36.3–405.5)	0.65	0.53	20.51	92.31	<6.53
MIP-1a	1.9 (1.1–2.6)	1.9 (1.3–2.3)	0.69	0.53	7.69	97.44	<0.55
MIP-1b	0.0 (0.0–0.0)	0.0 (0.0–0.0)	0.61	0.51	97.44	7.69	<31.06
VEGF	1486 (1004–1960)	1368 (550.5–2020)	0.24	0.58	28.21	92.31	<571.3
TNF-a	0.0 (0.0–8.5)	0.0 (0.0–4.3)	0.45	0.54	84.62	33.33	<5.32
IFNg	0.0 (0.0–15.6)	0.0 (0.0–7.7	0.18	0.57	71.79	41.03	<0.47

Table 4: Shown are the saliva marker levels (median levels and inter quartile ranges (in parenthesis) comparing active TB (PTB) participants with other respiratory diseases (ORD) with Area Under the ROC curve ranging between 0.51–0.58

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