Table 1 Demographic, clinical and parasitological data at admission by treatment arm (as per allocation)

Number of admitted patients

109

108

Female: Male

59:50

52:56

Mean (range) age (months)

70.3 (9–167)

66.8 (6–153)

Mean (SD) weight (kg)

18.6 (7.8)

18.0 (6.8)

Mean (SD) height (cm)

109.5 (21.8)

107.7 (20.6)

Malnourished (%)

31.2

23.5

A⁻ G6PD allele frequency (%)

18.3

15.7

Sickle cell trait allele frequency (%)

6.9

6.9

Palpable splenomegaly (%)

49.5

40.7

Hepatomegaly (%)

28.4

22.2

Median (range) Axillary temperature (°C)

37.1 °C (36.0–40.4)

37.0 °C (36.0–39.9)

Mean (SD) Systolic blood pressure (mmHg)

89 ± 8

89 ± 9

Mean (SD) Diastolic blood pressure (mmHg)

54 ± 8

53 ± 8

Mean (SD) Heart Rate (beats/ min)

125 ± 21

123 ± 21

Mean (SD) Respiratory Rate (breaths/min)

36 ± 8

34 ± 6

Mean (SD) WBC count, 10³/ΜL

8.0 (3.5)

7.3 (3.1)

Mean (SD) haemoglobin, g/dL

10.4 (1.7)

10.3 (1.8)

Mean (SD) haematocrit (%)

31.3 (4.9)

30.7 (5.3)

Median P. falciparum parasitaemia/μL (range)

179,608

(100,480–1,386,624)

177,473

(101,108–840,264)

Geometric mean P. falciparum density (/μL) (95% CI)

201,450

(181,764–223,268)

199,070

(181,496–218,346)

No. patients with >250,000/ΜL (%)

35.8%

41.7%

Geometric mean plasma PfHRP2 ng/mL (95% CI)

558.8 (N = 51)

(369.7–844.6)

564.7 (N = 47)

(344.7–925.1)

Median oi-RBC count/μL (range)

10,927

(0–104,499)

11,680

(0–145,947)