Table 1 Main gene mutations found among isolates conferring resistance
From: Emergence and clonal transmission of multi-drug-resistant tuberculosis among patients in Chad
Gene | Probes | Codon analysed for rpoB and katG. nucleic acid position for inhA | Developing mutation band | Mutation | Resistance INH N (%) 42 (13. 50) | Resistance RIF N (%) 17 (5.47) | MDR N (%) 14 (4.50) |
|---|---|---|---|---|---|---|---|
rpoB | WT7 | 526–529 | rpoB MUT2A | H526Y | - | 5 (1.61) | 0 |
rpoB MUT2B | H526D | 4 (1.29) | 0 | ||||
WT8 | 530–533 | rpoB MUT3 | S531 L | - | 8 (2.57) | 7 (2.25) | |
katG | WT | 315 | MUT1 | S315 T1 | 23 (7.40) | - | 7 (2.25) |
MUT2 | S315 T2 | - | |||||
inhA | WT1 | -15 | MUT1 | C15T | 19 (6.11) | - | - |