From: Outcomes from patients with presumed drug resistant tuberculosis in five reference centers in Brazil
Variable | DS-TB | DR/MDR-TB | Â | MDR-TB | p value | ||
---|---|---|---|---|---|---|---|
N (%) | N (%) | OR(95% CI) | p value | N (%) | OR(95% CI) | Â | |
Treatment and Laboratory results at Triage | |||||||
 AFB at triagem |  |  |  |  |  |  |  |
  Pos | 53(89.8) | 41(80.4) | 1.0 (Reference) | p = 0.34 | 24(77.4) | 1.0 (Reference) | p = 0.19 |
  Neg | 6(10.2) | 8(15.7) | 0.58(0.18–1.80) |  | 6(19.3) | 0.45 (0.13–1.55) |  |
  IGN | 0 | 2(3.9) |  |  | 1(3.2) |  |  |
 HIV testing result | |||||||
  Positive | 9(15.3) | 3(5.9) | 1.0 (Reference) | p = 0.06 | 3(9.7) | 1.0 (Reference) | p = 0.33 |
  Negative | 27(45.8) | 34(62.7) | 0.26(0.06–1.07) |  | 18(56.1) | 0.50 (0.11–2.10) |  |
  IGN | 11(38.9) | 14(27.4) | - |  | 10(32.2) |  |  |
 Chest X Ray(Images) | |||||||
  Typical | 56(94.8) | 45(88.2) | 1.0 (Reference) | p = 0.08 | 25(80.6) | 1.0 (Reference) | p = 0.01 |
  Compatible | 1(1.9) | 6(11.8) | 0.13(0.01–1.15) |  | 6(19.4) | 0.07(0.008–0.65) |  |
  Atipical | 2(3.3) | 0 | - |  | 0 |  |  |
 Cavitation | |||||||
  Yes | 52(88.1) | 40(78.4) | 1.0 (Reference) | p = 0.16 | 23(74.2) | 1.0 (Reference) | p = 0.19 |
  No | 6(10.0) | 10(19.5) | 0.46(0.15–1.37) |  | 7(22.6) | 0.37 (0.11–1.25) |  |
  IGN | 1(1.9) | 1(1.9) |  |  | 1(3.2) |  |  |
 Empirical treament | |||||||
  Yes | 58 (98.3) | 48(94.1) | 1.0 (Reference) | p = 0.51 | 28(90.3) | 1.0 (Reference) | p = 0.23 |
  1st line drugs | 51 | 34 | 0.27(0.02–2.73) |  | 12 | 0.16(0.01–1.61) |  |
  2nd line drugs | 7 | 14 |  |  | 16 |  |  |
  No | 1 (1.7) | 3 (5.9) |  |  | 3(9.7) |  |  |
 Anti_TB drugs prescribed at triage | |||||||
  Maintained the regimen | 18(30.5) | 18(35.3) | 1.0(Reference) | p = 0.59 | 12(38.7) | 1.0 (Reference) | p = 0.43 |
  Start new TB regimen | 41(69.5) | 33(64.7) | 1.24(0.56–2.76) |  | 19(61.3) | 1.44(0.57–3.57) |  |
Treatment and Laboratory results among 95 pDR-TB Followed-up | |||||||
 Adverse reaction | |||||||
  Yes | 7(15.6) | 11(22.0) | 1.0 (Reference) | p = 0.88 | 8(27.6) | 1.0 (Reference) | p = 0.82 |
  No | 20(44.5) | 34(68.0) | 0.92(0.30–2.76) |  | 20(68.9) | 1.14(0.34–3.75) |  |
  IGN | 18(40.0) | 5(10.0) |  |  | 1(3.4) |  |  |
 Change of treat | |||||||
  Yes | 9(20.0) | 27(54.0) | 1.0 (Reference) | p = 0.03 | 20(68.9) | 1.0 (Reference) | p < 0.01 |
  Use DST results | 3 | 21 | 2.85(1.06–7.60) |  | 16 | 4.69(1.53–14.34) |  |
  Other | 6 | 6 |  |  | 4 |  |  |
  No | 19(42.0) | 20(40.0) |  |  | 9(31.1) |  |  |
  IGN | 17(37.8) | 3(6.0) |  |  |  |  |  |
 AFB 6th month | |||||||
  Positive | 2(4.5) | 6(12.0) | 1.0 (Reference) | p = 0.35 | 4(13.8) | 1.0 (Reference) | p = 0.49 |
  Negative | 17(37.8) | 23(46.0) | 2.21(0.39–12.36) |  | 12(41.4) | 2.80(0.44–18.0) |  |
  IGN | 26(57.8) | 21 (42.0) |  |  | 13 (44.8) |  |  |
 Culture results 6th month | |||||||
  Pos | 1(2.2) | 10(20.0) | 1.0 (Reference) | p = 0.10 | 6(20.7) | 1.0 (Reference) | p = 0.17 |
  Neg | 12(26.7) | 17(34.0) | 7.05(0.79–62.72) |  | 11(37.9) | 6.54(0.67–63.33) |  |
  Cont | 1(2.2) | 1(2.0) | - |  | 0 |  |  |
  IGN | 31(68.9) | 22(44.0) |  |  | 12 (41.4) |  |  |
 Treatment Outcome at 6th month | |||||||
  Favourable | 23(51.0) | 33(66.0) | 2.42(1.02–5.78) | p = 0.04 | 21(72.4) | 2.51(0.92–6.84) | p = 0.07 |
  Unfavourable | 22(48.9) | 13(26.0) | 1.0 (Reference) |  | 8(27.6) | 1.0 (Reference) |  |
  Default | 20 | 2 |  |  | 1 |  |  |
  Failure | 1 | 10 |  |  | 6 |  |  |
  Death | 1 | 1 |  |  | 1 |  |  |
  Transfer | - | 4(8.0) |  |  |  |  |  |