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Table 4 Demographic, Behaviour and Clinical Characteristics of Presumed Drug Resistant TB at Triage

From: Outcomes from patients with presumed drug resistant tuberculosis in five reference centers in Brazil

  DS-TB DR/MDR-TB   MDR-TB p value
  N (%) N (%) OR(95% CI) p value N (%) OR(95% CI)
Demographic Characteristics
Sex
  Male 39(66.1) 33(64.7) 1.0 (Reference) p = 0.87 20(64.5) 1.0 (Reference) p = 0.88
  Female 20(33.9) 18(35.3) 0.94(0.42–2.06)   11(35.5) 1.07(0.43–2.67)  
 Age
   < 25 9(15.3) 6(11.8) 1.0 (Reference)   4(12.9) 1.0 (Reference)  
  26–45 34(57.6) 28(54.9) 0.81(0.25–2.55) p = 0,71 18(58.1) 0.83(0.22–3.10) p = 0.79
   > 45 16(27.1) 17(33.3) 0.62(0.18–2.16) p = 0.46 9(29.0) 0.79(0.18–3.31) p = 0.74
 Race
  White 20(33.9) 26(50.9) 1.0 (Reference) p = 0.07 16(51.6) 1.0 (Reference) p = 0.10
  Non White 39(63.1) 25(49.1) 2.02(0.94–4.37)   15(48.4) 2.08(0.85–5.05)  
 Schooling (Patient)
   < 8 years 54(91.5) 44(86.3) 1.0 (Reference) p = 0.54 27(87.1) 1.0 (Reference) p = 0.61
   > 8 years 4(6.8) 5(9.8) 0.65(0.16–2.57)   3(9.7) 2.66(0.14–3.20)  
  IGN 1(1.7) 2(3.9) -   1(3.2)   
Behavhiour characteristics
 Smoker
  Current 30(50.8) 18(35.3) 1.0 (Reference)   10(32.3) 1.0 (Reference) p = 0.10
  Ex 18(30.5) 17(33.3) 0.63(0.26–1.53) p = 0.31 11(35.4) 0.54(0.19–1.53) p = 0.25
  Never 10(16.8) 15(29.4) 0.40(0.14–1.07) p = 0.06 10(32.3) 0.33(0.10–1.03)  
  IGN 1(1.7) 1(2.0)    0   
 Alcoholism (CAGE)
  Yes 13(22.0) 7(13.7) 1.0 (Reference) p = 0.26 3(9.7) 1.0 (Reference)  
  No 46(78.0) 44(86.3) 0.56(0.20–1.54)
-
  28(90.3 0.37(0.09–1.44) p = 0.05
 Admission hospital last 2 years
  Yes 22(37.3) 15(29.4) 1.0 (Reference) p = 0.34 8(25.8) 1.0 (Reference) p = 0.24
  No 36(61.0) 36(70.6) 0.68(0.30–1.52)   23(74.2) 0.56(0.21–1.49)  
  IGN 1(1.7) 0 -   0   
 Admission prison last 2 years
  Yes 14(23.7) 7(13.7) 1.0 (Reference) p = 0.18 5(16.1) 1.0 (Reference) p = 0.40
  No 45(76.3) 44(86.3) 0.51(0.18–1.38)
-
  26(83.9) 0.61(0.19–1.91)  
 Admission in Shelters last 2 years
  Yes 5(8.5) 3(5.9) 1.0 (Reference) p = 0.60 3(9.7) 1.0 (Reference) p = 1.00
  No 53(89.8) 47(92.1) 0.67(0.15–2.98)   27(87.1) 1.17(0.26–5.30)  
  IGN 1(1.7) 1(2.0) -   1(3.2)   
Clinical Characteristics
 Contact of pulm TB
  Yes 29(49.2) 26(50.9) 1.0 (Reference) p = 0.95 19(61.3) 1.0 (Reference) p = 0.17
  No 24(40.7) 21(41.2) 1.02(0.46–2.25)   8(25;8) 1.96(0.73–5.27)  
  IGN 6(10.1) 4(7.9) -   4(12.9)   
 TB in the past
  Yes 48(81.3) 39(76.5) 1.0 (Reference) p = 0.66 23(74.2) 1.0 (Reference) p = 0.60
  No 11(18.7) 11(21.6) 0.81(0.31–2.07)   7(22.6) 0.75(0.25–2.19)  
  IGN 0 1(1.9) -   1(3.2)   
 Number treat in the past
  = > 3 16(27.1) 15(29.4) 1.0 (Reference) p = 0.62 9(29.0) 1.0 (Reference) p = 0.63
   < 3 32(54.2) 24(47.1) 1.25(0.51–3.01)   14(45.2) 1.28(0.45–3.60)  
  IGN 11(18.7) 12(23.5) -   8(25.8)   
 Outcome TB treat in the past
  Cure/complete 17(28.8) 8 (15.7) 1.0 (Reference) p = 0.17 3(9.6) 1.0 (Reference) p = 0.06
  Defaulting/failure 30(50.8) 28(54.9) 0.5(0.18–1.35)   19(61.3) 0.27 (0.07–1.08)  
  IGN 12(20.3) 15(29.4)    9(29.1)   
 Cough/Expectoration
  Yes 52(88.1) 43(84.3) 1.0 (Reference) p = 0.40 23(74.3) 1.0 (Reference) p = 0.06
  No 6(10.2) 8(15.7) 0.62(0.19–1.92)   8(25;8) 0.33(0.10–1.06)  
  IGN 1(1.7) 0 -   0   
 Hemoptysis
  Yes 13(22.0) 13(25.5) 1.0 (Reference) p = 0.70 6(19.3) 1.0 (Reference) p = 0.73
  No 45(76.3) 38(74.5) 1.18(0.49–2.86)   25(80.7) 0.83(0.28–2.45)  
  IGN 1(1.7) 0 -   0   
 Fever
  Yes 38(64.4) 29(56.8) 1.0 (Reference) p = 0.29 17(54.8) 1.0 (Reference) p = 0.22
  No 18(30.5) 21(41.2) 0.65(0.29–1.44)   14(45.2) 0.57(0.23–1.41)  
  IGN 3(5.1) 1(2.0) -   0   
 Weight loss
  Yes 49(83.1) 26(50.9) 4.71(1.96–11.3) p < 0.01 14(45.2) 1.0 (Reference) p < 0.01
  No 10(16.9) 25(49.1) 1.0 (Reference)   17(54.8) 5.95(2.23–15.87)  
 Sweating
  Yes 43(72.9) 25(49.0) 2.58(1.12–5.95) p = 0.04 13(41.9) 1.0 (Reference) p = 0.01
  No 14(23.6) 21(41.2) 1.0 (Reference)   15(48.4) 3.54(1.36–9.22)  
  IGN 2(2.5) 5(9.8) -   3(9.7)   
 Dyspneia
  Yes 44(74.6) 27(52.9) 2.39(1.05–5.44) p = 0.05 15(48.4) 1.0 (Reference) p = 0.02
  No 15(25.4) 22(43.1) 1.0 (Reference)   16(51.6) 3.18(1.28–7.93)  
 IGN 0 2(4.0)    0   
  1. IGN ignored, NA not applicable, MDR multidrugresistant, DR drug resistant, DS drug sensitive