Table 4 Demographic, Behaviour and Clinical Characteristics of Presumed Drug Resistant TB at Triage
From: Outcomes from patients with presumed drug resistant tuberculosis in five reference centers in Brazil
| DS-TB | DR/MDR-TB | MDR-TB | p value | ||||
|---|---|---|---|---|---|---|---|
| N (%) | N (%) | OR(95% CI) | p value | N (%) | OR(95% CI) | ||
| Demographic Characteristics | |||||||
| Sex | |||||||
| Male | 39(66.1) | 33(64.7) | 1.0 (Reference) | p = 0.87 | 20(64.5) | 1.0 (Reference) | p = 0.88 |
| Female | 20(33.9) | 18(35.3) | 0.94(0.42–2.06) | 11(35.5) | 1.07(0.43–2.67) | ||
| Age | |||||||
| < 25 | 9(15.3) | 6(11.8) | 1.0 (Reference) | 4(12.9) | 1.0 (Reference) | ||
| 26–45 | 34(57.6) | 28(54.9) | 0.81(0.25–2.55) | p = 0,71 | 18(58.1) | 0.83(0.22–3.10) | p = 0.79 |
| > 45 | 16(27.1) | 17(33.3) | 0.62(0.18–2.16) | p = 0.46 | 9(29.0) | 0.79(0.18–3.31) | p = 0.74 |
| Race | |||||||
| White | 20(33.9) | 26(50.9) | 1.0 (Reference) | p = 0.07 | 16(51.6) | 1.0 (Reference) | p = 0.10 |
| Non White | 39(63.1) | 25(49.1) | 2.02(0.94–4.37) | 15(48.4) | 2.08(0.85–5.05) | ||
| Schooling (Patient) | |||||||
| < 8 years | 54(91.5) | 44(86.3) | 1.0 (Reference) | p = 0.54 | 27(87.1) | 1.0 (Reference) | p = 0.61 |
| > 8 years | 4(6.8) | 5(9.8) | 0.65(0.16–2.57) | 3(9.7) | 2.66(0.14–3.20) | ||
| IGN | 1(1.7) | 2(3.9) | - | 1(3.2) | |||
| Behavhiour characteristics | |||||||
| Smoker | |||||||
| Current | 30(50.8) | 18(35.3) | 1.0 (Reference) | 10(32.3) | 1.0 (Reference) | p = 0.10 | |
| Ex | 18(30.5) | 17(33.3) | 0.63(0.26–1.53) | p = 0.31 | 11(35.4) | 0.54(0.19–1.53) | p = 0.25 |
| Never | 10(16.8) | 15(29.4) | 0.40(0.14–1.07) | p = 0.06 | 10(32.3) | 0.33(0.10–1.03) | |
| IGN | 1(1.7) | 1(2.0) | 0 | ||||
| Alcoholism (CAGE) | |||||||
| Yes | 13(22.0) | 7(13.7) | 1.0 (Reference) | p = 0.26 | 3(9.7) | 1.0 (Reference) | |
| No | 46(78.0) | 44(86.3) |
0.56(0.20–1.54) - | 28(90.3 | 0.37(0.09–1.44) | p = 0.05 | |
| Admission hospital last 2 years | |||||||
| Yes | 22(37.3) | 15(29.4) | 1.0 (Reference) | p = 0.34 | 8(25.8) | 1.0 (Reference) | p = 0.24 |
| No | 36(61.0) | 36(70.6) | 0.68(0.30–1.52) | 23(74.2) | 0.56(0.21–1.49) | ||
| IGN | 1(1.7) | 0 | - | 0 | |||
| Admission prison last 2 years | |||||||
| Yes | 14(23.7) | 7(13.7) | 1.0 (Reference) | p = 0.18 | 5(16.1) | 1.0 (Reference) | p = 0.40 |
| No | 45(76.3) | 44(86.3) |
0.51(0.18–1.38) - | 26(83.9) | 0.61(0.19–1.91) | ||
| Admission in Shelters last 2 years | |||||||
| Yes | 5(8.5) | 3(5.9) | 1.0 (Reference) | p = 0.60 | 3(9.7) | 1.0 (Reference) | p = 1.00 |
| No | 53(89.8) | 47(92.1) | 0.67(0.15–2.98) | 27(87.1) | 1.17(0.26–5.30) | ||
| IGN | 1(1.7) | 1(2.0) | - | 1(3.2) | |||
| Clinical Characteristics | |||||||
| Contact of pulm TB | |||||||
| Yes | 29(49.2) | 26(50.9) | 1.0 (Reference) | p = 0.95 | 19(61.3) | 1.0 (Reference) | p = 0.17 |
| No | 24(40.7) | 21(41.2) | 1.02(0.46–2.25) | 8(25;8) | 1.96(0.73–5.27) | ||
| IGN | 6(10.1) | 4(7.9) | - | 4(12.9) | |||
| TB in the past | |||||||
| Yes | 48(81.3) | 39(76.5) | 1.0 (Reference) | p = 0.66 | 23(74.2) | 1.0 (Reference) | p = 0.60 |
| No | 11(18.7) | 11(21.6) | 0.81(0.31–2.07) | 7(22.6) | 0.75(0.25–2.19) | ||
| IGN | 0 | 1(1.9) | - | 1(3.2) | |||
| Number treat in the past | |||||||
| = > 3 | 16(27.1) | 15(29.4) | 1.0 (Reference) | p = 0.62 | 9(29.0) | 1.0 (Reference) | p = 0.63 |
| < 3 | 32(54.2) | 24(47.1) | 1.25(0.51–3.01) | 14(45.2) | 1.28(0.45–3.60) | ||
| IGN | 11(18.7) | 12(23.5) | - | 8(25.8) | |||
| Outcome TB treat in the past | |||||||
| Cure/complete | 17(28.8) | 8 (15.7) | 1.0 (Reference) | p = 0.17 | 3(9.6) | 1.0 (Reference) | p = 0.06 |
| Defaulting/failure | 30(50.8) | 28(54.9) | 0.5(0.18–1.35) | 19(61.3) | 0.27 (0.07–1.08) | ||
| IGN | 12(20.3) | 15(29.4) | 9(29.1) | ||||
| Cough/Expectoration | |||||||
| Yes | 52(88.1) | 43(84.3) | 1.0 (Reference) | p = 0.40 | 23(74.3) | 1.0 (Reference) | p = 0.06 |
| No | 6(10.2) | 8(15.7) | 0.62(0.19–1.92) | 8(25;8) | 0.33(0.10–1.06) | ||
| IGN | 1(1.7) | 0 | - | 0 | |||
| Hemoptysis | |||||||
| Yes | 13(22.0) | 13(25.5) | 1.0 (Reference) | p = 0.70 | 6(19.3) | 1.0 (Reference) | p = 0.73 |
| No | 45(76.3) | 38(74.5) | 1.18(0.49–2.86) | 25(80.7) | 0.83(0.28–2.45) | ||
| IGN | 1(1.7) | 0 | - | 0 | |||
| Fever | |||||||
| Yes | 38(64.4) | 29(56.8) | 1.0 (Reference) | p = 0.29 | 17(54.8) | 1.0 (Reference) | p = 0.22 |
| No | 18(30.5) | 21(41.2) | 0.65(0.29–1.44) | 14(45.2) | 0.57(0.23–1.41) | ||
| IGN | 3(5.1) | 1(2.0) | - | 0 | |||
| Weight loss | |||||||
| Yes | 49(83.1) | 26(50.9) | 4.71(1.96–11.3) | p < 0.01 | 14(45.2) | 1.0 (Reference) | p < 0.01 |
| No | 10(16.9) | 25(49.1) | 1.0 (Reference) | 17(54.8) | 5.95(2.23–15.87) | ||
| Sweating | |||||||
| Yes | 43(72.9) | 25(49.0) | 2.58(1.12–5.95) | p = 0.04 | 13(41.9) | 1.0 (Reference) | p = 0.01 |
| No | 14(23.6) | 21(41.2) | 1.0 (Reference) | 15(48.4) | 3.54(1.36–9.22) | ||
| IGN | 2(2.5) | 5(9.8) | - | 3(9.7) | |||
| Dyspneia | |||||||
| Yes | 44(74.6) | 27(52.9) | 2.39(1.05–5.44) | p = 0.05 | 15(48.4) | 1.0 (Reference) | p = 0.02 |
| No | 15(25.4) | 22(43.1) | 1.0 (Reference) | 16(51.6) | 3.18(1.28–7.93) | ||
| IGN | 0 | 2(4.0) | 0 | ||||