Table 2 Parameter values including range used in sensitivity analysis
Parameter | Base value | Low value | High value | Distribution (Parametersa) | Source |
|---|---|---|---|---|---|
Probability HBsAg + for all women attending SMRU clinics | 0.07 | 0.07 | 0.08 | Beta (490.6, 6187.1) | SMRU data with 95% CI |
Probability HBeAg carrier if HBsAg+ | 0.34 | 0.29 | 0.39 | Beta (130.1, 253.6) | SMRU data with 95% CI |
Probability women receive antenatal care (attend clinic at least 7Â days before delivery) | 0.96 | 0.96 | 0.96 | Beta (999.9, 41.4) | SMRU data with 95% CI |
Probability of clinic delivery after attending antenatal care | 0.90 | 0.90 | 0.91 | Beta (999.9, 107.6) | SMRU data with 95% CI |
Probability that newborns birthed at home after attending antenatal care will receive HBV vaccine at the clinic (present within 12Â h) | 0.15 | 0.12 | 0.17 | Beta (94.3, 552.5) | SMRU data with 95% CI |
Probability of HBV perinatal infection for HBeAg- mothers without vaccination | 0.11 | 0.05 | 0.31 | Beta (1.7, 13.5) | |
Probability of HBV perinatal infection for HBeAg + mothers without vaccination | 0.84 | 0.66 | 1.00 | Beta (15.5, 2.95) | |
Probability of HBV perinatal infection for HBeAg- mothers if given vaccine | 0.07 | 0.00 | 0.13 | Beta (4.1, 57.9) | [7] |
Probability of HBV perinatal infection for HBeAg + mothers if given vaccine | 0.34 | 0.21 | 0.43 | Beta (24.3, 47.6) | [7] |
Probability of HBV perinatal infection for HBsAg- mothers if given vaccine and HBIG | 0.01 | 0.00 | 0.03 | Beta (1.6, 159.0) | [7] |
Probability of HBV perinatal infection for HBeAg + mothers if given vaccine and HBIG | 0.13 | 0.06 | 0.29 | Beta (3.1, 21.7) | [7] |
Sensitivity of the RDT for HBsAg | 0.98 | 0.90 | 1.00 | Beta (24.3, 0.5) | [44] with assumed range |
Specificity of the RDT for HBsAg | 0.97 | 0.95 | 0.98 | Beta (306.4, 9.9) | [29] with 95% CI |
Sensitivity of the confirmatory test for HBeAg | 1.00 | 0.90 | 1.00 | Beta (40.0, 0.0) | [43] with assumed range |
Specificity of the confirmatory test for HBeAg | 1.00 | 0.90 | 1.00 | Beta (40.0, 0.0) | [43] with assumed range |
Costs | |||||
 Cost of HBV vaccinations | 4.71 | 2.36 | 7.07 | Gamma (16.1, 0.3) | SMRU records ±50%. Cost of single vaccination at birth plus two doses of HBV diphtheria tetanus and pertussis combined vaccine given at 2 and 6 months |
 Cost of a RDT for HBsAg | 1.17 | 0.59 | 1.76 | Gamma (16.1, 0.1) | SMRU records ±50% |
 Cost of a confirmatory test for HBeAg at local hospital | 17.85 | 8.93 | 26.78 | Gamma (16.1, 1.1) | SMRU records ±50% |
 Cost per dose of HBIG | 43.00 | 21.50 | 64.50 | Gamma (16.1, 2.7) | SMRU records ±50% |