Fig. 2

Compartmental structure of transmission dynamic model. Recovery to susceptible compartments after successful completion of treatment, default with return to active disease, death and intervention-related flows are universally implemented but not presented in this Figure. Greater number of overlapping rectangles indicates greater degrees of model stratification, although number of rectangles is arbitrary. Flows presented are: 1, births; 2, infection; 3, progression to active disease; 4 and 5, spontaneous recovery; 6, missed diagnosis due to insensitivity of the diagnostic algorithm; 7, return to care seeking; 8, detection with correct assignment by drug resistance profile; 9, detection with incorrect assignment by drug resistance profile; 10 and 11, commencement on treatment. *“Organ involvement” refers to whether patient has smear-positive, smear-negative or extrapulmonary disease