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Table 3 Polymorphisms observed in the K13-propeller in 11 countries

From: Polymorphisms of Plasmodium falciparum k13-propeller gene among migrant workers returning to Henan Province, China from Africa

Country(n)

Codon position.

Amino acid reference

Nucleotide reference

Amino acid mutation

Nucleotide mutation

Prevalence of mutation (%)

Year (n)

Angola (102)

     

4.90(n = 5)

 

471a

R

CGT

R

CGC

1.96 (n = 2)

2013 (1), 2015 (1)

539b

R

AGA

T

ACA

0.98 (n = 1)

2014 (1)

579

M

ATG

I

ATT

0.98 (n = 1)

2015 (1)

613

Q

CAA

E

GAA

0.98 (n = 1)

2014 (1)

Zimbabwe(1)

     

100(n = 1)

 

664

N

AAT

D

GAT

100(n = 1)

2014 (1)

Uganda(4)

     

25(n = 1)

 

578

A

GCT

S

TCT

25(n = 1)

2015 (1)

Benin(5)

     

20(n = 1)

 

662

F

TTT

C

TGT

20(n = 1)1

2014 (1)

664

N

AAT

D

GAT

20(n = 1)1

 

Liberia(22)

     

9.09(n = 2)

 

629

N

AAT

S

AGT

4.55(n = 1)

2013 (1)

464

D

GAT

N

AAT

4.55(n = 1)

2012 (1)

Ghana(23)

     

4.35(n = 1)

 

648

D

GAT

N

AAT

4.35(n = 1)2

2012 (1)

664

N

AAT

D

GAT

4.35(n = 1)2

 

Sierra Leone(24)

     

4.17(n = 1)

 

556

E

GAA

K

AAA

4.17(n = 1)3

2014 (1)

648

D

GAT

Y

TAT

4.17(n = 1)3

 

Guinea(34)

     

2.94(n = 1)

 

578

A

GCT

S

TCT

2.94 (n = 1)

2015 (1)

Nigeria(72)

     

4.17(n = 3)

 

496a

G

GGT

G

GGC

0.14(n = 1)

2014 (1)

610

K

AAA

R

AGA

0.14 (n = 1)

2014 (1)

626

A

GCA

T

ACA

0.14(n = 1)4

2014 (1)

627a

A

GCT

A

GCA

0.14(n = 1)4

 

Congo, DRC(7)

     

14.29(n = 1)

 

613

Q

CAA

E

GAA

14.29(n = 1)

2014 (1)

Equatorial Guinea(65)

     

10.77(n = 7)

 

464

D

GAT

N

AAT

1.54(n = 1)

2014 (1)

476

M

ATG

I

ATA

1.54(n = 1)5

2013 (1)

589

V

GTC

I

ATC

1.54(n = 1)5

 

574b

P

CCT

L

CTT

1.54(n = 1)

2013 (1)

578

A

GCT

T

ACT

1.54(n = 1)6

2014 (1)

579

M

ATG

I

ATT

1.54(n = 1)6

 

658

K

AAA

Q

CAA

1.54(n = 1)

2014 (1)

663

L

CTA

V

GTA

1.54(n = 1)

2014 (1)

664a

N

AAT

N

AAC

1.54(n = 1)

2015 (1)

  1. The same number indicated that the two mutations were found in one sample
  2. aSynonymous mutation
  3. bMutations associated with ART resistance