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Table 3 Polymorphisms observed in the K13-propeller in 11 countries

From: Polymorphisms of Plasmodium falciparum k13-propeller gene among migrant workers returning to Henan Province, China from Africa

Country(n) Codon position. Amino acid reference Nucleotide reference Amino acid mutation Nucleotide mutation Prevalence of mutation (%) Year (n)
Angola (102)       4.90(n = 5)  
471a R CGT R CGC 1.96 (n = 2) 2013 (1), 2015 (1)
539b R AGA T ACA 0.98 (n = 1) 2014 (1)
579 M ATG I ATT 0.98 (n = 1) 2015 (1)
613 Q CAA E GAA 0.98 (n = 1) 2014 (1)
Zimbabwe(1)       100(n = 1)  
664 N AAT D GAT 100(n = 1) 2014 (1)
Uganda(4)       25(n = 1)  
578 A GCT S TCT 25(n = 1) 2015 (1)
Benin(5)       20(n = 1)  
662 F TTT C TGT 20(n = 1)1 2014 (1)
664 N AAT D GAT 20(n = 1)1  
Liberia(22)       9.09(n = 2)  
629 N AAT S AGT 4.55(n = 1) 2013 (1)
464 D GAT N AAT 4.55(n = 1) 2012 (1)
Ghana(23)       4.35(n = 1)  
648 D GAT N AAT 4.35(n = 1)2 2012 (1)
664 N AAT D GAT 4.35(n = 1)2  
Sierra Leone(24)       4.17(n = 1)  
556 E GAA K AAA 4.17(n = 1)3 2014 (1)
648 D GAT Y TAT 4.17(n = 1)3  
Guinea(34)       2.94(n = 1)  
578 A GCT S TCT 2.94 (n = 1) 2015 (1)
Nigeria(72)       4.17(n = 3)  
496a G GGT G GGC 0.14(n = 1) 2014 (1)
610 K AAA R AGA 0.14 (n = 1) 2014 (1)
626 A GCA T ACA 0.14(n = 1)4 2014 (1)
627a A GCT A GCA 0.14(n = 1)4  
Congo, DRC(7)       14.29(n = 1)  
613 Q CAA E GAA 14.29(n = 1) 2014 (1)
Equatorial Guinea(65)       10.77(n = 7)  
464 D GAT N AAT 1.54(n = 1) 2014 (1)
476 M ATG I ATA 1.54(n = 1)5 2013 (1)
589 V GTC I ATC 1.54(n = 1)5  
574b P CCT L CTT 1.54(n = 1) 2013 (1)
578 A GCT T ACT 1.54(n = 1)6 2014 (1)
579 M ATG I ATT 1.54(n = 1)6  
658 K AAA Q CAA 1.54(n = 1) 2014 (1)
663 L CTA V GTA 1.54(n = 1) 2014 (1)
664a N AAT N AAC 1.54(n = 1) 2015 (1)
  1. The same number indicated that the two mutations were found in one sample
  2. aSynonymous mutation
  3. bMutations associated with ART resistance